Can Radiotherapy Empower the Host Immune System to Counterattack Neoplastic Cells? A Systematic Review on Tumor Microenvironment Radiomodulation

Can Radiotherapy Empower the Host Immune System to Counterattack Neoplastic Cells? A Systematic Review on Tumor Microenvironment Radiomodulation

Despite the rising evidence in favor of immunotherapy (IT), the treatment of oncological patients affected by so-called “cold tumors” still represents an open issue. Cold tumors are characterized by an immunosuppressive (so-called cold) tumor microenvironment (TME), which favors host immune system s...

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Bibliographic Details
Main Authors: Federico Iori, Alessio Bruni, Salvatore Cozzi, Patrizia Ciammella, Francesca Di Pressa, Luca Boldrini, Carlo Greco, Valerio Nardone, Viola Salvestrini, Isacco Desideri, Francesca De Felice, Cinzia Iotti
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Current Oncology
Subjects:
radiotherapy
tumor microenvironment
cold tumors
radiomodulation
immune escape
abscopal effect
Online Access:https://www.mdpi.com/1718-7729/29/7/366

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