PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell
Pharmacokinetics and pharmacodynamics (PKPD) are key considerations in any study of molecular therapies. It is thus imperative to factor their effects into any in silico model of biological tissue involving such therapies. Furthermore, creating a standardized and flexible framework will benefit the...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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GigaScience Press
2022-11-01
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| Series: | GigaByte |
| Online Access: | https://gigabytejournal.com/articles/72 |
| _version_ | 1826583955009175552 |
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| author | Daniel Bergman Lauren Marazzi Mukti Chowkwale Deepa Maheshvare M Supriya Bidanta Tarunendu Mapder Jialun Li |
| author_facet | Daniel Bergman Lauren Marazzi Mukti Chowkwale Deepa Maheshvare M Supriya Bidanta Tarunendu Mapder Jialun Li |
| author_sort | Daniel Bergman |
| collection | DOAJ |
| description |
Pharmacokinetics and pharmacodynamics (PKPD) are key considerations in any study of molecular therapies. It is thus imperative to factor their effects into any in silico model of biological tissue involving such therapies. Furthermore, creating a standardized and flexible framework will benefit the community by increasing access to such modules and enhancing their communicability. PhysiCell is an open-source physics-based cell simulator, i.e., a platform for modeling biological tissue, that is quickly being adopted and utilized by the mathematical biology community. We present here PhysiPKPD, an open-source PhysiCell-based package that allows users to include PKPD in PhysiCell models.
Availability & Implementation
The source code for PhysiPKPD is located here: https://github.com/drbergman/PhysiPKPD.
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| first_indexed | 2024-03-13T00:22:31Z |
| format | Article |
| id | doaj.art-aaa9dfc48af54a42843b2b04519d69bc |
| institution | Directory Open Access Journal |
| issn | 2709-4715 |
| language | English |
| last_indexed | 2025-03-14T15:30:04Z |
| publishDate | 2022-11-01 |
| publisher | GigaScience Press |
| record_format | Article |
| series | GigaByte |
| spelling | doaj.art-aaa9dfc48af54a42843b2b04519d69bc2025-02-25T06:24:28ZengGigaScience PressGigaByte2709-47152022-11-0110.46471/gigabyte.72PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCellDaniel Bergman 0https://orcid.org/0000-0002-2166-6616Lauren Marazzi 1https://orcid.org/0000-0002-7425-9467Mukti Chowkwale 2https://orcid.org/0000-0001-9761-1235Deepa Maheshvare M 3https://orcid.org/0000-0002-8879-8357Supriya Bidanta 4Tarunendu Mapder 5https://orcid.org/0000-0002-1630-0716Jialun Li 6Department of Mathematics, University of Michigan, Ann Arbor, MI 48109, USACenter for Quantitative Medicine, University of Connecticut School of Medicine, Farmington, CT 06030, USADepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA 22908, USADepartment of Computational and Data Sciences, Indian Institute of Science, Bengaluru 560012, IndiaIndiana University, Bloomington, IN 47405, USAQuantitative Systems Pharmacology, Bristol-Myers Squibb, Princeton Lawrenceville, NJ, USAMcGill University, Montréal, QC H3A 0G4, Canada Pharmacokinetics and pharmacodynamics (PKPD) are key considerations in any study of molecular therapies. It is thus imperative to factor their effects into any in silico model of biological tissue involving such therapies. Furthermore, creating a standardized and flexible framework will benefit the community by increasing access to such modules and enhancing their communicability. PhysiCell is an open-source physics-based cell simulator, i.e., a platform for modeling biological tissue, that is quickly being adopted and utilized by the mathematical biology community. We present here PhysiPKPD, an open-source PhysiCell-based package that allows users to include PKPD in PhysiCell models. Availability & Implementation The source code for PhysiPKPD is located here: https://github.com/drbergman/PhysiPKPD. https://gigabytejournal.com/articles/72 |
| spellingShingle | Daniel Bergman Lauren Marazzi Mukti Chowkwale Deepa Maheshvare M Supriya Bidanta Tarunendu Mapder Jialun Li PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell GigaByte |
| title | PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell |
| title_full | PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell |
| title_fullStr | PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell |
| title_full_unstemmed | PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell |
| title_short | PhysiPKPD: A pharmacokinetics and pharmacodynamics module for PhysiCell |
| title_sort | physipkpd a pharmacokinetics and pharmacodynamics module for physicell |
| url | https://gigabytejournal.com/articles/72 |
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