PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11
Objective of the work was to determine protective potential and safety for animals of the naturally attenuated B. anthracis 363/11 monoplazmid non-capsular strain to be used as a new candidate vaccine strain for the development and enhancement of specific prophylaxis of anthrax. Materials and method...
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2017-06-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/399 |
| _version_ | 1797220823687233536 |
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| author | T. A. Sevskikh Yu. O. Selyaninov I. Yu. Egorova |
| author_facet | T. A. Sevskikh Yu. O. Selyaninov I. Yu. Egorova |
| author_sort | T. A. Sevskikh |
| collection | DOAJ |
| description | Objective of the work was to determine protective potential and safety for animals of the naturally attenuated B. anthracis 363/11 monoplazmid non-capsular strain to be used as a new candidate vaccine strain for the development and enhancement of specific prophylaxis of anthrax. Materials and methods. Vaccine strain 55-VNIIVViM that is used for welfare provision as regards anthrax in animals in the territory of Russia was employed for the comparison of protective properties. Identification of LD50, ImD50 and protective efficacy was carried out using standard protocols for modeling the infection on laboratory (white mice, guinea pigs) and targeted (sheep) animals. Results and conclusions. It is established that avirulent for white mice B. anthracis 363/11 strain demonstrates higher protective and immunogenic activity than 55-VNIIVViM strain. It does not reverse to the virulent variant after passaging on the nutrient media and in the organism of susceptible animals. Thus it allows for considering B. anthracis 363/11 strain as a promising candidate vaccine strain, the utilization of which will improve epizootic situation on anthrax in the Russian Federation. |
| first_indexed | 2024-03-08T13:42:36Z |
| format | Article |
| id | doaj.art-aaab1388281845caad3d461e1782c9ff |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:55:40Z |
| publishDate | 2017-06-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-aaab1388281845caad3d461e1782c9ff2024-04-05T16:47:12ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2017-06-0102848610.21055/0370-1069-2017-2-84-86399PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11T. A. Sevskikh0Yu. O. Selyaninov1I. Yu. Egorova2National Research Institute of Veterinary Virology and Microbiology, Russian Academy of Agricultural ScienceNational Research Institute of Veterinary Virology and Microbiology, Russian Academy of Agricultural ScienceNational Research Institute of Veterinary Virology and Microbiology, Russian Academy of Agricultural ScienceObjective of the work was to determine protective potential and safety for animals of the naturally attenuated B. anthracis 363/11 monoplazmid non-capsular strain to be used as a new candidate vaccine strain for the development and enhancement of specific prophylaxis of anthrax. Materials and methods. Vaccine strain 55-VNIIVViM that is used for welfare provision as regards anthrax in animals in the territory of Russia was employed for the comparison of protective properties. Identification of LD50, ImD50 and protective efficacy was carried out using standard protocols for modeling the infection on laboratory (white mice, guinea pigs) and targeted (sheep) animals. Results and conclusions. It is established that avirulent for white mice B. anthracis 363/11 strain demonstrates higher protective and immunogenic activity than 55-VNIIVViM strain. It does not reverse to the virulent variant after passaging on the nutrient media and in the organism of susceptible animals. Thus it allows for considering B. anthracis 363/11 strain as a promising candidate vaccine strain, the utilization of which will improve epizootic situation on anthrax in the Russian Federation.https://journal.microbe.ru/jour/article/view/399b. anthracisimmunogenic activityprotectivitycandidate vaccine |
| spellingShingle | T. A. Sevskikh Yu. O. Selyaninov I. Yu. Egorova PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 Проблемы особо опасных инфекций b. anthracis immunogenic activity protectivity candidate vaccine |
| title | PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 |
| title_full | PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 |
| title_fullStr | PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 |
| title_full_unstemmed | PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 |
| title_short | PROTECTIVE PROPERTIES OF THE VACCINE STRAIN 55-VNIIVVIM AND ACAPSULAR STRAIN BACILLUS ANTHRACIS 363/11 |
| title_sort | protective properties of the vaccine strain 55 vniivvim and acapsular strain bacillus anthracis 363 11 |
| topic | b. anthracis immunogenic activity protectivity candidate vaccine |
| url | https://journal.microbe.ru/jour/article/view/399 |
| work_keys_str_mv | AT tasevskikh protectivepropertiesofthevaccinestrain55vniivvimandacapsularstrainbacillusanthracis36311 AT yuoselyaninov protectivepropertiesofthevaccinestrain55vniivvimandacapsularstrainbacillusanthracis36311 AT iyuegorova protectivepropertiesofthevaccinestrain55vniivvimandacapsularstrainbacillusanthracis36311 |