tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors
BackgroundMemory impairment is among one of the greatest cognitive complaints in midlife and in old age. Considering the importance of good memory functioning in everyday life, it is crucial to study interventions that can reduce the natural decline in this cognitive function. Transcranial Magnetic...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.814003/full |
| _version_ | 1828894650449002496 |
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| author | Maria Cotelli Clarissa Ferrari Elena Gobbi Giuliano Binetti Rosa Manenti Marco Sandrini |
| author_facet | Maria Cotelli Clarissa Ferrari Elena Gobbi Giuliano Binetti Rosa Manenti Marco Sandrini |
| author_sort | Maria Cotelli |
| collection | DOAJ |
| description | BackgroundMemory impairment is among one of the greatest cognitive complaints in midlife and in old age. Considering the importance of good memory functioning in everyday life, it is crucial to study interventions that can reduce the natural decline in this cognitive function. Transcranial Magnetic Stimulation (TMS) studies have demonstrated that the lateral prefrontal cortex (PFC) plays a causal role in enhancing episodic memory recall through reconsolidation. Using a similar paradigm with transcranial direct current stimulation (tDCS) over the left lateral PFC, facilitation effects were observed in delayed memory retrieval in older adults with subjective memory complaints (SMCs) and amnestic Mild Cognitive Impairment (aMCI). However, it remains unclear which potential factors (i.e., tDCS group, cognitive reserve, education level, diagnosis and encoding performance) directly and/or indirectly modulate the tDCS-induced memory reconsolidation effects.MethodsWe reanalyzed data acquired in our previous tDCS studies with 22 SMC and 18 aMCI participants from the perspective of predicting delayed memory retrieval performance. These studies included a learning session on Day 1, a reactivation by a contextual reminder followed by 15 min of tDCS session on Day 2 (24 h after Day 1), and two retrieval sessions (free recall and recognition) tested on Days 3 and 30 (48 h and 30 Days after Day 1).ResultsUnivariate models showed that tDCS group (sham vs. active) significantly predicted memory recognition (but not free recall), evidenced by higher scores in the active tDCS group than in sham group, confirming our previous results. Encoding performance and diagnosis (SMC vs. aMCI) significantly predicted memory retrieval, suggesting higher performances in individuals with SMC than in those with aMCI. Regarding cognitive reserve, higher leisure time activity subscores significantly predicted better memory recognition. Finally, multiple models did not show any tDCS group × predictor interaction effects, indicating that the effects of the predictors on retrieval occurred irrespective of tDCS group.ConclusionOur results shed light on predicting factors of episodic memory retrieval in this reconsolidation paradigm in individuals with SMC and aMCI. The findings suggest that multifactorial interventions program may be most promising to slow cognitive decline and delay the onset of dementia. |
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| id | doaj.art-aaaf0f792f3c4649a5f6c6d6346d2606 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-13T14:15:22Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neuroscience |
| spelling | doaj.art-aaaf0f792f3c4649a5f6c6d6346d26062022-12-21T23:42:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-03-011610.3389/fnins.2022.814003814003tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting FactorsMaria Cotelli0Clarissa Ferrari1Elena Gobbi2Giuliano Binetti3Rosa Manenti4Marco Sandrini5Neuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyStatistics Service, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyMAC Memory Clinic and Molecular Markers Laboratory, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalyNeuropsychology Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, ItalySchool of Psychology, University of Roehampton, London, United KingdomBackgroundMemory impairment is among one of the greatest cognitive complaints in midlife and in old age. Considering the importance of good memory functioning in everyday life, it is crucial to study interventions that can reduce the natural decline in this cognitive function. Transcranial Magnetic Stimulation (TMS) studies have demonstrated that the lateral prefrontal cortex (PFC) plays a causal role in enhancing episodic memory recall through reconsolidation. Using a similar paradigm with transcranial direct current stimulation (tDCS) over the left lateral PFC, facilitation effects were observed in delayed memory retrieval in older adults with subjective memory complaints (SMCs) and amnestic Mild Cognitive Impairment (aMCI). However, it remains unclear which potential factors (i.e., tDCS group, cognitive reserve, education level, diagnosis and encoding performance) directly and/or indirectly modulate the tDCS-induced memory reconsolidation effects.MethodsWe reanalyzed data acquired in our previous tDCS studies with 22 SMC and 18 aMCI participants from the perspective of predicting delayed memory retrieval performance. These studies included a learning session on Day 1, a reactivation by a contextual reminder followed by 15 min of tDCS session on Day 2 (24 h after Day 1), and two retrieval sessions (free recall and recognition) tested on Days 3 and 30 (48 h and 30 Days after Day 1).ResultsUnivariate models showed that tDCS group (sham vs. active) significantly predicted memory recognition (but not free recall), evidenced by higher scores in the active tDCS group than in sham group, confirming our previous results. Encoding performance and diagnosis (SMC vs. aMCI) significantly predicted memory retrieval, suggesting higher performances in individuals with SMC than in those with aMCI. Regarding cognitive reserve, higher leisure time activity subscores significantly predicted better memory recognition. Finally, multiple models did not show any tDCS group × predictor interaction effects, indicating that the effects of the predictors on retrieval occurred irrespective of tDCS group.ConclusionOur results shed light on predicting factors of episodic memory retrieval in this reconsolidation paradigm in individuals with SMC and aMCI. The findings suggest that multifactorial interventions program may be most promising to slow cognitive decline and delay the onset of dementia.https://www.frontiersin.org/articles/10.3389/fnins.2022.814003/fullhealthy older adultssubjective memory complaintsmild cognitive impairmentmemorycognitive reserve |
| spellingShingle | Maria Cotelli Clarissa Ferrari Elena Gobbi Giuliano Binetti Rosa Manenti Marco Sandrini tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors Frontiers in Neuroscience healthy older adults subjective memory complaints mild cognitive impairment memory cognitive reserve |
| title | tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors |
| title_full | tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors |
| title_fullStr | tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors |
| title_full_unstemmed | tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors |
| title_short | tDCS-Induced Memory Reconsolidation Effects: Analysis of Prominent Predicting Factors |
| title_sort | tdcs induced memory reconsolidation effects analysis of prominent predicting factors |
| topic | healthy older adults subjective memory complaints mild cognitive impairment memory cognitive reserve |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.814003/full |
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