Stiff person syndrome with negative anti-gad 65 antibodies. Case report
We present a case of 42-year-old woman without significant medical history, admitted in our clinic for painful neck stiffness, aggravated by emotions and stress relieved during sleep, accompanied by sweating, predominantly lower limbs weakness. The symptoms insidiously appeared one month prior prese...
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| Format: | Article |
| Language: | English |
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Amaltea Medical Publishing House
2013-09-01
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| Series: | Romanian Journal of Neurology |
| Subjects: | |
| Online Access: | https://rjn.com.ro/articles/2013.3/RJN_2013_3_Art-10.pdf |
| _version_ | 1811229114059718656 |
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| author | Corina Roman-Filip Daniela Radu Aurelian Ungureanu Adelina Deaconu Marcel Pereanu |
| author_facet | Corina Roman-Filip Daniela Radu Aurelian Ungureanu Adelina Deaconu Marcel Pereanu |
| author_sort | Corina Roman-Filip |
| collection | DOAJ |
| description | We present a case of 42-year-old woman without significant medical history, admitted in our clinic for painful neck stiffness, aggravated by emotions and stress relieved during sleep, accompanied by sweating, predominantly lower limbs weakness. The symptoms insidiously appeared one month prior presentation. On neurological examination we found painful paravertebral and laterocervical muscle contracture and spastic paraparesis. Laboratory tests included the analysis of anti-glutamic acid decarboxylase (anti-GAD65) and anti-Borrelia antibodies, carcinoma antigens (CA 125, CA 15-3) which were found negative. Cerebrospinal fluid analysis found positive oligoclonal bands with a slight increase of IgG component. Other tests including thyroid function were found normal. Brain and spinal MRI examinations showed no changes. Methylprednisolone, baclofen and carbamazepine were administered without a significant improvement. After 4 months from the first admission, the patient returns with increased symptoms for which plasma exchange achieved a slight improvement of motor deficit and rigidity. Stiff person syndrome is thought to be triggered by anti-GAD antibodies that limit the GABA receptor activity, although about 10 to 40% of the patients do not shows these antibodies in the serum. |
| first_indexed | 2024-04-12T10:09:06Z |
| format | Article |
| id | doaj.art-aaaf1af0abce484ba86883bde79451e7 |
| institution | Directory Open Access Journal |
| issn | 1843-8148 2069-6094 |
| language | English |
| last_indexed | 2024-04-12T10:09:06Z |
| publishDate | 2013-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj.art-aaaf1af0abce484ba86883bde79451e72022-12-22T03:37:21ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942013-09-0112315615910.37897/RJN.2013.3.10Stiff person syndrome with negative anti-gad 65 antibodies. Case reportCorina Roman-Filip0Daniela Radu1Aurelian Ungureanu2Adelina Deaconu3Marcel Pereanu4Department of Neurology, “Lucian Blaga” University SibiuDepartment of Neurology, Sibiu Emergency Clinical County HospitalDepartment of Neurology, Sibiu Emergency Clinical County HospitalDepartment of Neurology, Sibiu Emergency Clinical County HospitalDepartment of Neurology, “Lucian Blaga” University SibiuWe present a case of 42-year-old woman without significant medical history, admitted in our clinic for painful neck stiffness, aggravated by emotions and stress relieved during sleep, accompanied by sweating, predominantly lower limbs weakness. The symptoms insidiously appeared one month prior presentation. On neurological examination we found painful paravertebral and laterocervical muscle contracture and spastic paraparesis. Laboratory tests included the analysis of anti-glutamic acid decarboxylase (anti-GAD65) and anti-Borrelia antibodies, carcinoma antigens (CA 125, CA 15-3) which were found negative. Cerebrospinal fluid analysis found positive oligoclonal bands with a slight increase of IgG component. Other tests including thyroid function were found normal. Brain and spinal MRI examinations showed no changes. Methylprednisolone, baclofen and carbamazepine were administered without a significant improvement. After 4 months from the first admission, the patient returns with increased symptoms for which plasma exchange achieved a slight improvement of motor deficit and rigidity. Stiff person syndrome is thought to be triggered by anti-GAD antibodies that limit the GABA receptor activity, although about 10 to 40% of the patients do not shows these antibodies in the serum.https://rjn.com.ro/articles/2013.3/RJN_2013_3_Art-10.pdfanti-gad antibodiesstiff person syndrome |
| spellingShingle | Corina Roman-Filip Daniela Radu Aurelian Ungureanu Adelina Deaconu Marcel Pereanu Stiff person syndrome with negative anti-gad 65 antibodies. Case report Romanian Journal of Neurology anti-gad antibodies stiff person syndrome |
| title | Stiff person syndrome with negative anti-gad 65 antibodies. Case report |
| title_full | Stiff person syndrome with negative anti-gad 65 antibodies. Case report |
| title_fullStr | Stiff person syndrome with negative anti-gad 65 antibodies. Case report |
| title_full_unstemmed | Stiff person syndrome with negative anti-gad 65 antibodies. Case report |
| title_short | Stiff person syndrome with negative anti-gad 65 antibodies. Case report |
| title_sort | stiff person syndrome with negative anti gad 65 antibodies case report |
| topic | anti-gad antibodies stiff person syndrome |
| url | https://rjn.com.ro/articles/2013.3/RJN_2013_3_Art-10.pdf |
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