Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis
Abstract Introduction Out‐of‐hospital cardiac arrest (OHCA) is defined as the loss of functional mechanical activity of the heart in association with an absence of systemic circulation, occurring outside of a hospital. Immediate coronary angiography (CAG) with percutaneous coronary intervention is r...
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| Format: | Article |
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Wiley
2024-02-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.1379 |
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| author | Khalid Rashid Muhammad Aamir Waheed Farrukh Ansar Abdelrahman M. Makram Ahmedyar Hasan Shahab Ahmed Saad Tariq Khan Aamer Ubaid Ahmad Al Ibad Rabia Basri Omar Mohamed Makram Yahya Khan Nabhan Rashad Abdelnaser Elzouki |
| author_facet | Khalid Rashid Muhammad Aamir Waheed Farrukh Ansar Abdelrahman M. Makram Ahmedyar Hasan Shahab Ahmed Saad Tariq Khan Aamer Ubaid Ahmad Al Ibad Rabia Basri Omar Mohamed Makram Yahya Khan Nabhan Rashad Abdelnaser Elzouki |
| author_sort | Khalid Rashid |
| collection | DOAJ |
| description | Abstract Introduction Out‐of‐hospital cardiac arrest (OHCA) is defined as the loss of functional mechanical activity of the heart in association with an absence of systemic circulation, occurring outside of a hospital. Immediate coronary angiography (CAG) with percutaneous coronary intervention is recommended for OHCA with ST‐elevation. We aimed to evaluate the effect of early CAG on mortality and neurological outcomes in OHCA patients without ST‐elevation. Methods This meta‐analysis and systemic review was conducted as per principles of Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) group. A protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO, Ref No. = CRD42022327833). A total of 674 studies were retrieved after scanning several databases (PubMed Central, EMBASE, Medline, and Cochrane Central Register of Controlled Trials). Results A total of 18 studies were selected for the final analysis, including 6 randomized control trials and 12 observational studies. Statistically, there was no significant difference in primary outcome, i.e., mortality, between early and delayed CAG. In terms of the grade of neurological recovery as a secondary outcome, early and delayed CAG groups also showed no statistically significant difference. Conclusion Early CAG has no survival benefits in patients with no ST elevations on ECG after OHCA. |
| first_indexed | 2024-03-07T19:01:36Z |
| format | Article |
| id | doaj.art-aaaf281d91ef459baddbc7f5461a0c36 |
| institution | Directory Open Access Journal |
| issn | 2398-8835 |
| language | English |
| last_indexed | 2024-04-24T13:01:04Z |
| publishDate | 2024-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj.art-aaaf281d91ef459baddbc7f5461a0c362024-04-05T11:41:32ZengWileyHealth Science Reports2398-88352024-02-0172n/an/a10.1002/hsr2.1379Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysisKhalid Rashid0Muhammad Aamir Waheed1Farrukh Ansar2Abdelrahman M. Makram3Ahmedyar Hasan4Shahab Ahmed5Saad Tariq Khan6Aamer Ubaid7Ahmad Al Ibad8Rabia Basri9Omar Mohamed Makram10Yahya Khan11Nabhan Rashad12Abdelnaser Elzouki13Internal Medicine James Cook University Hospital Middlesbrough UKDepartment of Medicine Hamad Medical Corporation Doha QatarDepartment of Medicine Quaid e Azam International Hospital Islamabad PakistanPublic health, School of Public Health Imperial College London London UKDepartment of Medicine Mohammed Bin Rashid University of Medicine and Health Sciences Dubai UAEMedicine King Abdullah Teaching Hospital Mansehra PakistanInternal Medicine Sunderland Royal Hospital Sunderland UKInternal Medicine University of Missouri Kansas City Kansas City Missouri USAInternal Medicine Bannu Medical College Bannu PakistanDepartment of Medicine Hamad Medical Corporation Doha QatarPublic health, Faculty of Public Health and Policy London School of Hygiene and Tropical Medicine London UKMardan Medical Complex Mardan PakistanDepartment of Medicine Khyber Teaching Hospital Peshawar PakistanDepartment of Medicine, Hamad General Hospital Weill Cornell Medicine Ar‐Rayyan QatarAbstract Introduction Out‐of‐hospital cardiac arrest (OHCA) is defined as the loss of functional mechanical activity of the heart in association with an absence of systemic circulation, occurring outside of a hospital. Immediate coronary angiography (CAG) with percutaneous coronary intervention is recommended for OHCA with ST‐elevation. We aimed to evaluate the effect of early CAG on mortality and neurological outcomes in OHCA patients without ST‐elevation. Methods This meta‐analysis and systemic review was conducted as per principles of Preferred Reporting Items for Systematic Reviews and Meta‐analysis (PRISMA) group. A protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO, Ref No. = CRD42022327833). A total of 674 studies were retrieved after scanning several databases (PubMed Central, EMBASE, Medline, and Cochrane Central Register of Controlled Trials). Results A total of 18 studies were selected for the final analysis, including 6 randomized control trials and 12 observational studies. Statistically, there was no significant difference in primary outcome, i.e., mortality, between early and delayed CAG. In terms of the grade of neurological recovery as a secondary outcome, early and delayed CAG groups also showed no statistically significant difference. Conclusion Early CAG has no survival benefits in patients with no ST elevations on ECG after OHCA.https://doi.org/10.1002/hsr2.1379coronary angiographyearly vs delayed CAGout‐of‐hospital cardiac arrestpercutaneous coronary intervention |
| spellingShingle | Khalid Rashid Muhammad Aamir Waheed Farrukh Ansar Abdelrahman M. Makram Ahmedyar Hasan Shahab Ahmed Saad Tariq Khan Aamer Ubaid Ahmad Al Ibad Rabia Basri Omar Mohamed Makram Yahya Khan Nabhan Rashad Abdelnaser Elzouki Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis Health Science Reports coronary angiography early vs delayed CAG out‐of‐hospital cardiac arrest percutaneous coronary intervention |
| title | Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis |
| title_full | Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis |
| title_fullStr | Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis |
| title_full_unstemmed | Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis |
| title_short | Early coronary angioplasty fails to lower all‐cause mortality in patients with out‐of‐hospital cardiac arrest without ST‐segment elevation: A systematic review and meta‐analysis |
| title_sort | early coronary angioplasty fails to lower all cause mortality in patients with out of hospital cardiac arrest without st segment elevation a systematic review and meta analysis |
| topic | coronary angiography early vs delayed CAG out‐of‐hospital cardiac arrest percutaneous coronary intervention |
| url | https://doi.org/10.1002/hsr2.1379 |
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