Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups
Abstract Background Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of developing various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be different, but studies on PBM children of different age groups are limited...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-023-04248-y |
| _version_ | 1797556387283206144 |
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| author | Hui-min Mao Shun-gen Huang Yang Yang Tian-na Cai Lin Fang Wan-liang Guo |
| author_facet | Hui-min Mao Shun-gen Huang Yang Yang Tian-na Cai Lin Fang Wan-liang Guo |
| author_sort | Hui-min Mao |
| collection | DOAJ |
| description | Abstract Background Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of developing various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be different, but studies on PBM children of different age groups are limited. This study was to evaluate clinicopathologic characteristics and outcomes in PBM children of different ages. Methods A total of 166 pediatric patients with PBM were reviewed retrospectively. Clinicopathological, imaging, laboratory, surgical, and follow-up data were collected and analyzed. The patients were divided into three age groups, namely, group A (< 1 year, n = 31), group B (1–3 years, n = 63), and group C (> 3 years, n = 72). Results The major clinical manifestation was jaundice in group A and abdominal pain and vomiting in groups B and C. Acute pancreatitis was more often seen in group C than group A. The length of common channel was significantly longer in group C than group A, while the maximum diameter of common bile duct in group C was smaller than that in group A. Cholangitis and cholecystitis were more commonly performed in groups B and C, while hepatic fibrosis in group A. Whether preoperatively or postoperatively, group C was more likely to have elevated serum amylase, while groups A and B were more likely to present with abnormal liver function indicators, including the increase of aspartate transaminase, alanine transaminase, and gamma-glutamyl transpeptidase. Conclusion Presentation of PBM varies among different pediatric age groups, thus suggesting that targeted management should be carried out according to these differences. |
| first_indexed | 2024-03-10T17:02:07Z |
| format | Article |
| id | doaj.art-aaaf7e804b30490faf511c8bc8fb7253 |
| institution | Directory Open Access Journal |
| issn | 1471-2431 |
| language | English |
| last_indexed | 2024-03-10T17:02:07Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pediatrics |
| spelling | doaj.art-aaaf7e804b30490faf511c8bc8fb72532023-11-20T10:56:25ZengBMCBMC Pediatrics1471-24312023-08-012311910.1186/s12887-023-04248-yClinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groupsHui-min Mao0Shun-gen Huang1Yang Yang2Tian-na Cai3Lin Fang4Wan-liang Guo5Department of Radiology, Children’s Hospital of Soochow UniversityPediatric Surgery, Children’s Hospital of Soochow UniversityDepartment of Radiology, Children’s Hospital of Soochow UniversityDepartment of Radiology, Children’s Hospital of Soochow UniversityDepartment of Radiology, Children’s Hospital of Soochow UniversityDepartment of Radiology, Children’s Hospital of Soochow UniversityAbstract Background Pancreaticobiliary maljunction (PBM) is a congenital defect, with risk of developing various pancreaticobiliary and hepatic complications. The presentations of PBM in children and adults are believed to be different, but studies on PBM children of different age groups are limited. This study was to evaluate clinicopathologic characteristics and outcomes in PBM children of different ages. Methods A total of 166 pediatric patients with PBM were reviewed retrospectively. Clinicopathological, imaging, laboratory, surgical, and follow-up data were collected and analyzed. The patients were divided into three age groups, namely, group A (< 1 year, n = 31), group B (1–3 years, n = 63), and group C (> 3 years, n = 72). Results The major clinical manifestation was jaundice in group A and abdominal pain and vomiting in groups B and C. Acute pancreatitis was more often seen in group C than group A. The length of common channel was significantly longer in group C than group A, while the maximum diameter of common bile duct in group C was smaller than that in group A. Cholangitis and cholecystitis were more commonly performed in groups B and C, while hepatic fibrosis in group A. Whether preoperatively or postoperatively, group C was more likely to have elevated serum amylase, while groups A and B were more likely to present with abnormal liver function indicators, including the increase of aspartate transaminase, alanine transaminase, and gamma-glutamyl transpeptidase. Conclusion Presentation of PBM varies among different pediatric age groups, thus suggesting that targeted management should be carried out according to these differences.https://doi.org/10.1186/s12887-023-04248-yAgeChildrenClinical presentationOutcomesPancreaticobiliary maljunction |
| spellingShingle | Hui-min Mao Shun-gen Huang Yang Yang Tian-na Cai Lin Fang Wan-liang Guo Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups BMC Pediatrics Age Children Clinical presentation Outcomes Pancreaticobiliary maljunction |
| title | Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| title_full | Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| title_fullStr | Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| title_full_unstemmed | Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| title_short | Clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| title_sort | clinical presentations and outcomes of pancreaticobiliary maljunction in different pediatric age groups |
| topic | Age Children Clinical presentation Outcomes Pancreaticobiliary maljunction |
| url | https://doi.org/10.1186/s12887-023-04248-y |
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