An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders
Abstract Background Evidence mapping is a structured approach used to synthesize the state-of-the-art in an emerging field of research when systematic reviews or meta-analyses are deemed inappropriate. We employed this strategy to summarise knowledge regarding longitudinal ecological monitoring of r...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2020-12-01
|
| Series: | International Journal of Bipolar Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40345-020-00200-6 |
| _version_ | 1819072616638447616 |
|---|---|
| author | Jan Scott Francesc Colom Allan Young Frank Bellivier Bruno Etain |
| author_facet | Jan Scott Francesc Colom Allan Young Frank Bellivier Bruno Etain |
| author_sort | Jan Scott |
| collection | DOAJ |
| description | Abstract Background Evidence mapping is a structured approach used to synthesize the state-of-the-art in an emerging field of research when systematic reviews or meta-analyses are deemed inappropriate. We employed this strategy to summarise knowledge regarding longitudinal ecological monitoring of rest-activity rhythms (RAR) and disease modifiers, course of illness, treatment response or outcome in bipolar disorders (BD). Structure We had two key aims: (1) to determine the number and type of actigraphy studies of in BD that explored data regarding: outcome over time (e.g. relapse/recurrence according to polarity, or recovery/remission), treatment response or illness trajectories and (2) to examine the range of actigraphy metrics that can be used to estimate disruptions of RAR and describe which individual circadian rhythm or sleep–wake cycle parameters are most consistently associated with outcome over time in BD. The mapping process incorporated four steps: clarifying the project focus, describing boundaries and ‘coordinates’ for mapping, searching the literature and producing a brief synopsis with summary charts of the key outputs. Twenty-seven independent studies (reported in 29 publications) were eligible for inclusion in the map. Most were small-scale, with the median sample size being 15 per study and median duration of actigraphy being about 7 days (range 1–210). Interestingly, 17 studies comprised wholly or partly of inpatients (63%). The available evidence indicated that a discrete number of RAR metrics are more consistently associated with transition between different phases of BD and/or may be predictive of longitudinal course of illness or treatment response. The metrics that show the most frequent associations represent markers of the amount, timing, or variability of RAR rather than the sleep quality metrics that are frequently targeted in contemporary studies of BD. Conclusions Despite 50 years of research, use of actigraphy to assess RAR in longitudinal studies and examination of these metrics and treatment response, course and outcome of BD is under-investigated. This is in marked contrast to the extensive literature on case–control or cross-sectional studies of actigraphy, especially typical sleep analysis metrics in BD. However, given the encouraging findings on putative RAR markers, we recommend increased study of putative circadian phenotypes of BD. |
| first_indexed | 2024-12-21T17:40:34Z |
| format | Article |
| id | doaj.art-aab07f21c8974910bca627b795c7a68e |
| institution | Directory Open Access Journal |
| issn | 2194-7511 |
| language | English |
| last_indexed | 2024-12-21T17:40:34Z |
| publishDate | 2020-12-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | International Journal of Bipolar Disorders |
| spelling | doaj.art-aab07f21c8974910bca627b795c7a68e2022-12-21T18:55:38ZengSpringerOpenInternational Journal of Bipolar Disorders2194-75112020-12-018112210.1186/s40345-020-00200-6An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disordersJan Scott0Francesc Colom1Allan Young2Frank Bellivier3Bruno Etain4Institute of Neuroscience, Newcastle UniversityIMIM-Hospital del Mar-CIBERSAMCentre for Affective Disorders, Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King’s College LondonUniversité Paris Diderot, Sorbonne Paris Cité, UMR-S 1144Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1144Abstract Background Evidence mapping is a structured approach used to synthesize the state-of-the-art in an emerging field of research when systematic reviews or meta-analyses are deemed inappropriate. We employed this strategy to summarise knowledge regarding longitudinal ecological monitoring of rest-activity rhythms (RAR) and disease modifiers, course of illness, treatment response or outcome in bipolar disorders (BD). Structure We had two key aims: (1) to determine the number and type of actigraphy studies of in BD that explored data regarding: outcome over time (e.g. relapse/recurrence according to polarity, or recovery/remission), treatment response or illness trajectories and (2) to examine the range of actigraphy metrics that can be used to estimate disruptions of RAR and describe which individual circadian rhythm or sleep–wake cycle parameters are most consistently associated with outcome over time in BD. The mapping process incorporated four steps: clarifying the project focus, describing boundaries and ‘coordinates’ for mapping, searching the literature and producing a brief synopsis with summary charts of the key outputs. Twenty-seven independent studies (reported in 29 publications) were eligible for inclusion in the map. Most were small-scale, with the median sample size being 15 per study and median duration of actigraphy being about 7 days (range 1–210). Interestingly, 17 studies comprised wholly or partly of inpatients (63%). The available evidence indicated that a discrete number of RAR metrics are more consistently associated with transition between different phases of BD and/or may be predictive of longitudinal course of illness or treatment response. The metrics that show the most frequent associations represent markers of the amount, timing, or variability of RAR rather than the sleep quality metrics that are frequently targeted in contemporary studies of BD. Conclusions Despite 50 years of research, use of actigraphy to assess RAR in longitudinal studies and examination of these metrics and treatment response, course and outcome of BD is under-investigated. This is in marked contrast to the extensive literature on case–control or cross-sectional studies of actigraphy, especially typical sleep analysis metrics in BD. However, given the encouraging findings on putative RAR markers, we recommend increased study of putative circadian phenotypes of BD.https://doi.org/10.1186/s40345-020-00200-6Evidence mapActigraphyLongitudinalBipolarResponseCourse |
| spellingShingle | Jan Scott Francesc Colom Allan Young Frank Bellivier Bruno Etain An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders International Journal of Bipolar Disorders Evidence map Actigraphy Longitudinal Bipolar Response Course |
| title | An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders |
| title_full | An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders |
| title_fullStr | An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders |
| title_full_unstemmed | An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders |
| title_short | An evidence map of actigraphy studies exploring longitudinal associations between rest-activity rhythms and course and outcome of bipolar disorders |
| title_sort | evidence map of actigraphy studies exploring longitudinal associations between rest activity rhythms and course and outcome of bipolar disorders |
| topic | Evidence map Actigraphy Longitudinal Bipolar Response Course |
| url | https://doi.org/10.1186/s40345-020-00200-6 |
| work_keys_str_mv | AT janscott anevidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT francesccolom anevidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT allanyoung anevidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT frankbellivier anevidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT brunoetain anevidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT janscott evidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT francesccolom evidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT allanyoung evidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT frankbellivier evidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders AT brunoetain evidencemapofactigraphystudiesexploringlongitudinalassociationsbetweenrestactivityrhythmsandcourseandoutcomeofbipolardisorders |