The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up
Background/Aims: Giant peptic ulcers (GPUs) are detrimental for all patients, especially for children. However, few reports have described GPUs in children. This study aims to evaluate the characteristics of GPUs in Chinese children and to identify risk factors. Patients and Methods: We retrospectiv...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2018-01-01
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| Series: | The Saudi Journal of Gastroenterology |
| Subjects: | |
| Online Access: | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=6;spage=360;epage=364;aulast=Tang |
| _version_ | 1828759435112087552 |
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| author | Zifei Tang Jieru Shi Min Ji Peng Shi Zhiheng Huang Ying Huang |
| author_facet | Zifei Tang Jieru Shi Min Ji Peng Shi Zhiheng Huang Ying Huang |
| author_sort | Zifei Tang |
| collection | DOAJ |
| description | Background/Aims: Giant peptic ulcers (GPUs) are detrimental for all patients, especially for children. However, few reports have described GPUs in children. This study aims to evaluate the characteristics of GPUs in Chinese children and to identify risk factors.
Patients and Methods: We retrospectively analyzed patients at the Children's Hospital of Fudan University from April 2014 to August 2017. Patients with GPUs (>2.0 cm) were included in the study, and the clinical data, pathological characteristics and presence of Helicobacter pylori (H. pylori) infection were analyzed to evaluate the outcomes.
Results: A total of 19208 children underwent gastroscopic examinations, and 83 patients with GPUs were enrolled. The mean age of onset for GPU patients was 9.7 ± 3.2 years(range, 1-15). The main complaints were abdominal pain (92.7%), anemia (53%), retching (45.8%), hematochezia (21.7%) and hematemesis (16.9%). With respect to the types of GPU, 68 patients (81.9%) had duodenal ulcers, and 15 patients (18.1%) had gastric ulcers. Compared to the group <6 years of age, the group ≥6 years was more susceptible to GPU (P < 0.05). Among GPU patients, 71.1% of cases were H. pylori (*) (59/83), and 16.9% (14/83) of patients were H. pylori (-). Compared to the H. pylori (-) group, the H. pylori (*) group showed inflammatory activity, atrophy and lymphoid follicular formation in the gastric mucosa (P < 0.05).
Conclusions: This study suggests that GPUs are strongly associated with H. pylori infection in Chinese children. Duodenal ulcers are the main type of GPU in patients older than 6 years. Appropriate diagnosis, treatment and follow-up are necessary for children with GPUs. |
| first_indexed | 2024-12-11T00:58:05Z |
| format | Article |
| id | doaj.art-aab1820c18434dffa420179c7571e329 |
| institution | Directory Open Access Journal |
| issn | 1319-3767 1998-4049 |
| language | English |
| last_indexed | 2024-12-11T00:58:05Z |
| publishDate | 2018-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | The Saudi Journal of Gastroenterology |
| spelling | doaj.art-aab1820c18434dffa420179c7571e3292022-12-22T01:26:25ZengWolters Kluwer Medknow PublicationsThe Saudi Journal of Gastroenterology1319-37671998-40492018-01-0124636036410.4103/sjg.SJG_147_18The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-upZifei TangJieru ShiMin JiPeng ShiZhiheng HuangYing HuangBackground/Aims: Giant peptic ulcers (GPUs) are detrimental for all patients, especially for children. However, few reports have described GPUs in children. This study aims to evaluate the characteristics of GPUs in Chinese children and to identify risk factors. Patients and Methods: We retrospectively analyzed patients at the Children's Hospital of Fudan University from April 2014 to August 2017. Patients with GPUs (>2.0 cm) were included in the study, and the clinical data, pathological characteristics and presence of Helicobacter pylori (H. pylori) infection were analyzed to evaluate the outcomes. Results: A total of 19208 children underwent gastroscopic examinations, and 83 patients with GPUs were enrolled. The mean age of onset for GPU patients was 9.7 ± 3.2 years(range, 1-15). The main complaints were abdominal pain (92.7%), anemia (53%), retching (45.8%), hematochezia (21.7%) and hematemesis (16.9%). With respect to the types of GPU, 68 patients (81.9%) had duodenal ulcers, and 15 patients (18.1%) had gastric ulcers. Compared to the group <6 years of age, the group ≥6 years was more susceptible to GPU (P < 0.05). Among GPU patients, 71.1% of cases were H. pylori (*) (59/83), and 16.9% (14/83) of patients were H. pylori (-). Compared to the H. pylori (-) group, the H. pylori (*) group showed inflammatory activity, atrophy and lymphoid follicular formation in the gastric mucosa (P < 0.05). Conclusions: This study suggests that GPUs are strongly associated with H. pylori infection in Chinese children. Duodenal ulcers are the main type of GPU in patients older than 6 years. Appropriate diagnosis, treatment and follow-up are necessary for children with GPUs.http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=6;spage=360;epage=364;aulast=TangChinese childrengiant duodenal ulcersgiant gastric ulcersgiant peptic ulcersHelicobacter pylori |
| spellingShingle | Zifei Tang Jieru Shi Min Ji Peng Shi Zhiheng Huang Ying Huang The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up The Saudi Journal of Gastroenterology Chinese children giant duodenal ulcers giant gastric ulcers giant peptic ulcers Helicobacter pylori |
| title | The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up |
| title_full | The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up |
| title_fullStr | The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up |
| title_full_unstemmed | The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up |
| title_short | The characteristics of 83 giant peptic ulcers in Chinese children: Evaluation and follow-up |
| title_sort | characteristics of 83 giant peptic ulcers in chinese children evaluation and follow up |
| topic | Chinese children giant duodenal ulcers giant gastric ulcers giant peptic ulcers Helicobacter pylori |
| url | http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2018;volume=24;issue=6;spage=360;epage=364;aulast=Tang |
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