Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation

Sequestration of Intestinal Acidic Toxins by Cationic Resin Attenuates Pancreatic Cancer Progression through Promoting Autophagic Flux for YAP Degradation

Pancreatic cancer is driven by risk factors such as diabetes and chronic pancreatic injury, which are further associated with gut dysbiosis. Intestinal toxins such as bile acids and bacterial endotoxin (LPS), in excess and persistence, can provoke chronic inflammation and tumorigenesis. Of interest...

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Bibliographic Details
Main Authors: Guangfu Zhao, Tianci Zhang, Wei Liu, Mouad Edderkaoui, Richard Hu, Jun Li, Stephen J. Pandol, Xiangsheng Fu, Yuan-Ping Han
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
pancreatic cancer
yes-associated protein
bile acid
endotoxin
autophagy
lysosome
Online Access:https://www.mdpi.com/2072-6694/14/6/1407

Internet

https://www.mdpi.com/2072-6694/14/6/1407

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