Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer
Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/5/925 |
| _version_ | 1797599146548396032 |
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| author | Melanie Schubert Dirk Olaf Bauerschlag Mustafa Zelal Muallem Nicolai Maass Ibrahim Alkatout |
| author_facet | Melanie Schubert Dirk Olaf Bauerschlag Mustafa Zelal Muallem Nicolai Maass Ibrahim Alkatout |
| author_sort | Melanie Schubert |
| collection | DOAJ |
| description | Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it possible to provide individualized surgical and drug treatment. In industrialized countries, cervical cancer has become a less frequent tumor entity due to the accessibility of the human papilloma virus vaccination, systematic preventive programs/early detection programs, health care infrastructure and the availability of effective therapy options. Nevertheless, globally, neither mortality nor morbidity has been significantly reduced over the past 10 years, and therapy approaches differ widely. The aim of this review is to address recent advances in the prevention, diagnostic investigation and treatment of cervical cancer globally, focusing on advances in Germany, with a view toward providing an updated overview for clinicians. The following aspects are addressed in detail: (a) the prevalence and causes of cervical cancer, (b) diagnostic tools using imaging techniques, cytology and pathology, (c) pathomechanisms and clinical symptoms of cervical cancer and (d) different treatment approaches (pharmacological, surgical and others) and their impact on outcomes. |
| first_indexed | 2024-03-11T03:31:33Z |
| format | Article |
| id | doaj.art-aab560a5268b46e792d650d5bd6c8731 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T03:31:33Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-aab560a5268b46e792d650d5bd6c87312023-11-18T02:22:23ZengMDPI AGMedicina1010-660X1648-91442023-05-0159592510.3390/medicina59050925Challenges in the Diagnosis and Individualized Treatment of Cervical CancerMelanie Schubert0Dirk Olaf Bauerschlag1Mustafa Zelal Muallem2Nicolai Maass3Ibrahim Alkatout4Department of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Gynecology with Center for Oncological Surgery, Charité–Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Virchow Campus Clinic, 13353 Berlin, GermanyDepartment of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Obstetrics and Gynecology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, GermanyCervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it possible to provide individualized surgical and drug treatment. In industrialized countries, cervical cancer has become a less frequent tumor entity due to the accessibility of the human papilloma virus vaccination, systematic preventive programs/early detection programs, health care infrastructure and the availability of effective therapy options. Nevertheless, globally, neither mortality nor morbidity has been significantly reduced over the past 10 years, and therapy approaches differ widely. The aim of this review is to address recent advances in the prevention, diagnostic investigation and treatment of cervical cancer globally, focusing on advances in Germany, with a view toward providing an updated overview for clinicians. The following aspects are addressed in detail: (a) the prevalence and causes of cervical cancer, (b) diagnostic tools using imaging techniques, cytology and pathology, (c) pathomechanisms and clinical symptoms of cervical cancer and (d) different treatment approaches (pharmacological, surgical and others) and their impact on outcomes.https://www.mdpi.com/1648-9144/59/5/925cervical cancerHPVnerve-sparing radical hysterectomyradiochemotherapycheckpoint inhibitors |
| spellingShingle | Melanie Schubert Dirk Olaf Bauerschlag Mustafa Zelal Muallem Nicolai Maass Ibrahim Alkatout Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer Medicina cervical cancer HPV nerve-sparing radical hysterectomy radiochemotherapy checkpoint inhibitors |
| title | Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer |
| title_full | Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer |
| title_fullStr | Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer |
| title_full_unstemmed | Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer |
| title_short | Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer |
| title_sort | challenges in the diagnosis and individualized treatment of cervical cancer |
| topic | cervical cancer HPV nerve-sparing radical hysterectomy radiochemotherapy checkpoint inhibitors |
| url | https://www.mdpi.com/1648-9144/59/5/925 |
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