The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery
Cleft lip and palate is the fourth most common congenital malformation. Its prevalence is about 1 in 750 to 1 in 2000 live births. The consequences of this malformation are major: maxillary growth deficit, unaesthetic appearance, phonation disorders, difficulty in eating, and psycho-social disorders...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-10-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/11/1553 |
| _version_ | 1797511160917917696 |
|---|---|
| author | Damien Brézulier Louis Chaigneau Sylvie Jeanne Ronan Lebullenger |
| author_facet | Damien Brézulier Louis Chaigneau Sylvie Jeanne Ronan Lebullenger |
| author_sort | Damien Brézulier |
| collection | DOAJ |
| description | Cleft lip and palate is the fourth most common congenital malformation. Its prevalence is about 1 in 750 to 1 in 2000 live births. The consequences of this malformation are major: maxillary growth deficit, unaesthetic appearance, phonation disorders, difficulty in eating, and psycho-social disorders. Cleft palate repair establishes the division between the oral and nasal cavities. The alveolar bone graft is a key step. Different sites of autogenous bone harvesting are used, the most common being the iliac crest. Nevertheless, the large number of complications associated with harvesting has led to the use of substitute biomaterials. Bioactive glasses, discovered in 1969, are a group of synthetic silica-based materials with bone-bonding properties. Although 45S5 granular composition is commonly used in bone surgery to repair critical defects, it is only rarely used in the repair of cleft palates because this galenic form is only moderately adapted. However, advances in bone tissue engineering allow the shaping of three-dimensional scaffolds, which support colonization by host cells. Recent advances in computer-aided design/computer-aided manufacturing (CAD/CAM) have even led to the 3D printing of scaffolds combining 45S5 bioglass with a natural and biocompatible poly-lactic acid matrix. The shape of the parts is customized and adapted to the particular shape of the critical bone defects. The objective of this literature review is to highlight the particularities of alveolar defects subsequent to facial clefts, then to detail the characteristics of the materials and technologies used to elaborate 3D matrices by bioprinting. Finally, we will explore research directions regarding their use in reconstructive surgery of cleft palates. |
| first_indexed | 2024-03-10T05:41:31Z |
| format | Article |
| id | doaj.art-aab7d727796844b0bb28ec0f9b64f2d4 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T05:41:31Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-aab7d727796844b0bb28ec0f9b64f2d42023-11-22T22:29:56ZengMDPI AGBiomedicines2227-90592021-10-01911155310.3390/biomedicines9111553The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate SurgeryDamien Brézulier0Louis Chaigneau1Sylvie Jeanne2Ronan Lebullenger3CNRS, University of Rennes, ISCR-UMR 6226, 35000 Rennes, FranceCNRS, University of Rennes, ISCR-UMR 6226, 35000 Rennes, FranceCNRS, University of Rennes, ISCR-UMR 6226, 35000 Rennes, FranceCNRS, University of Rennes, ISCR-UMR 6226, 35000 Rennes, FranceCleft lip and palate is the fourth most common congenital malformation. Its prevalence is about 1 in 750 to 1 in 2000 live births. The consequences of this malformation are major: maxillary growth deficit, unaesthetic appearance, phonation disorders, difficulty in eating, and psycho-social disorders. Cleft palate repair establishes the division between the oral and nasal cavities. The alveolar bone graft is a key step. Different sites of autogenous bone harvesting are used, the most common being the iliac crest. Nevertheless, the large number of complications associated with harvesting has led to the use of substitute biomaterials. Bioactive glasses, discovered in 1969, are a group of synthetic silica-based materials with bone-bonding properties. Although 45S5 granular composition is commonly used in bone surgery to repair critical defects, it is only rarely used in the repair of cleft palates because this galenic form is only moderately adapted. However, advances in bone tissue engineering allow the shaping of three-dimensional scaffolds, which support colonization by host cells. Recent advances in computer-aided design/computer-aided manufacturing (CAD/CAM) have even led to the 3D printing of scaffolds combining 45S5 bioglass with a natural and biocompatible poly-lactic acid matrix. The shape of the parts is customized and adapted to the particular shape of the critical bone defects. The objective of this literature review is to highlight the particularities of alveolar defects subsequent to facial clefts, then to detail the characteristics of the materials and technologies used to elaborate 3D matrices by bioprinting. Finally, we will explore research directions regarding their use in reconstructive surgery of cleft palates.https://www.mdpi.com/2227-9059/9/11/1553biomaterialsregenerative medicinecleft palatebioglassbioprintingadditive manufacturing |
| spellingShingle | Damien Brézulier Louis Chaigneau Sylvie Jeanne Ronan Lebullenger The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery Biomedicines biomaterials regenerative medicine cleft palate bioglass bioprinting additive manufacturing |
| title | The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery |
| title_full | The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery |
| title_fullStr | The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery |
| title_full_unstemmed | The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery |
| title_short | The Challenge of 3D Bioprinting of Composite Natural Polymers PLA/Bioglass: Trends and Benefits in Cleft Palate Surgery |
| title_sort | challenge of 3d bioprinting of composite natural polymers pla bioglass trends and benefits in cleft palate surgery |
| topic | biomaterials regenerative medicine cleft palate bioglass bioprinting additive manufacturing |
| url | https://www.mdpi.com/2227-9059/9/11/1553 |
| work_keys_str_mv | AT damienbrezulier thechallengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT louischaigneau thechallengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT sylviejeanne thechallengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT ronanlebullenger thechallengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT damienbrezulier challengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT louischaigneau challengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT sylviejeanne challengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery AT ronanlebullenger challengeof3dbioprintingofcompositenaturalpolymersplabioglasstrendsandbenefitsincleftpalatesurgery |