Human Lung Organoids—A Novel Experimental and Precision Medicine Approach
The global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/16/2067 |
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| author | Laura Kühl Pauline Graichen Nele von Daacke Anne Mende Malgorzata Wygrecka Daniel P. Potaczek Sarah Miethe Holger Garn |
| author_facet | Laura Kühl Pauline Graichen Nele von Daacke Anne Mende Malgorzata Wygrecka Daniel P. Potaczek Sarah Miethe Holger Garn |
| author_sort | Laura Kühl |
| collection | DOAJ |
| description | The global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human lung organoids have been established as highly transferrable three-dimensional in vitro model systems for lung research. For acute infectious and chronic inflammatory diseases as well as lung cancer, human lung organoids have opened possibilities for precise in vitro research and a deeper understanding of mechanisms underlying lung injury and regeneration. Human lung organoids from induced pluripotent stem cells or from adult stem cells of patients’ samples introduce tools for understanding developmental processes and personalized medicine approaches. When further state-of-the-art technologies and protocols come into use, the full potential of human lung organoids can be harnessed. High-throughput assays in drug development, gene therapy, and organoid transplantation are current applications of organoids in translational research. In this review, we emphasize novel approaches in translational and personalized medicine in lung research focusing on the use of human lung organoids. |
| first_indexed | 2024-03-11T00:03:37Z |
| format | Article |
| id | doaj.art-aab89a53017b436893314cd476521c24 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T00:03:37Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-aab89a53017b436893314cd476521c242023-11-19T00:36:58ZengMDPI AGCells2073-44092023-08-011216206710.3390/cells12162067Human Lung Organoids—A Novel Experimental and Precision Medicine ApproachLaura Kühl0Pauline Graichen1Nele von Daacke2Anne Mende3Malgorzata Wygrecka4Daniel P. Potaczek5Sarah Miethe6Holger Garn7Translational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyCenter for Infection and Genomics of the Lung (CIGL), Universities of Giessen and Marburg Lung Center (UGMLC), 35392 Giessen, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyTranslational Inflammation Research Division & Core Facility for Single Cell Multiomics, Medical Faculty, Philipps University of Marburg, Member of the German Center for Lung Research (DZL) and the Universities of Giessen and Marburg Lung Center, 35043 Marburg, GermanyThe global burden of respiratory diseases is very high and still on the rise, prompting the need for accurate models for basic and translational research. Several model systems are currently available ranging from simple airway cell cultures to complex tissue-engineered lungs. In recent years, human lung organoids have been established as highly transferrable three-dimensional in vitro model systems for lung research. For acute infectious and chronic inflammatory diseases as well as lung cancer, human lung organoids have opened possibilities for precise in vitro research and a deeper understanding of mechanisms underlying lung injury and regeneration. Human lung organoids from induced pluripotent stem cells or from adult stem cells of patients’ samples introduce tools for understanding developmental processes and personalized medicine approaches. When further state-of-the-art technologies and protocols come into use, the full potential of human lung organoids can be harnessed. High-throughput assays in drug development, gene therapy, and organoid transplantation are current applications of organoids in translational research. In this review, we emphasize novel approaches in translational and personalized medicine in lung research focusing on the use of human lung organoids.https://www.mdpi.com/2073-4409/12/16/2067disease modelslung epitheliumairwaysorganoidspersonalized medicinetranslational research |
| spellingShingle | Laura Kühl Pauline Graichen Nele von Daacke Anne Mende Malgorzata Wygrecka Daniel P. Potaczek Sarah Miethe Holger Garn Human Lung Organoids—A Novel Experimental and Precision Medicine Approach Cells disease models lung epithelium airways organoids personalized medicine translational research |
| title | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
| title_full | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
| title_fullStr | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
| title_full_unstemmed | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
| title_short | Human Lung Organoids—A Novel Experimental and Precision Medicine Approach |
| title_sort | human lung organoids a novel experimental and precision medicine approach |
| topic | disease models lung epithelium airways organoids personalized medicine translational research |
| url | https://www.mdpi.com/2073-4409/12/16/2067 |
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