Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm
Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Ther...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/14/5368 |
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| author | Jinghong Shi Yucheng Wang Wei He Ziyue Ye Mengli Liu Zheng Zhao Jacky Wing Yip Lam Pengfei Zhang Ryan Tsz Kin Kwok Ben Zhong Tang |
| author_facet | Jinghong Shi Yucheng Wang Wei He Ziyue Ye Mengli Liu Zheng Zhao Jacky Wing Yip Lam Pengfei Zhang Ryan Tsz Kin Kwok Ben Zhong Tang |
| author_sort | Jinghong Shi |
| collection | DOAJ |
| description | Biofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed a type I photosensitizer (TTTDM) with an aggregation-induced emission (AIE) property and used F-127 to encapsulate the TTTDM into nanoparticles (F-127 AIE NPs). The NPs exhibit highly efficient ROS generation by enhancing intramolecular D–A interaction and confining molecular non-radiative transitions. Furthermore, the NPs can sufficiently penetrate the biofilm matrix and then detect and eliminate mature bacterial biofilms upon white light irradiation. This strategy holds great promise for the rapid detection and eradication of bacterial biofilms. |
| first_indexed | 2024-03-11T00:48:08Z |
| format | Article |
| id | doaj.art-aab923c9062f4d1fa169f93e18f3176d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:48:08Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-aab923c9062f4d1fa169f93e18f3176d2023-11-18T20:41:06ZengMDPI AGMolecules1420-30492023-07-012814536810.3390/molecules28145368Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of BiofilmJinghong Shi0Yucheng Wang1Wei He2Ziyue Ye3Mengli Liu4Zheng Zhao5Jacky Wing Yip Lam6Pengfei Zhang7Ryan Tsz Kin Kwok8Ben Zhong Tang9Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSchool of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong, Shenzhen 518172, ChinaDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaSchool of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong, Shenzhen 518172, ChinaSchool of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong, Shenzhen 518172, ChinaDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaShenzhen Key Laboratory for Molecular Imaging, CAS Key Lab for Health Informatics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, ChinaDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaDepartment of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, ChinaBiofilm-associated infections exert more severe and harmful attacks on human health since they can accelerate the generation and development of the antibiotic resistance of the embedded bacteria. Anti-biofilm materials and techniques that can eliminate biofilms effectively are in urgent demand. Therefore, we designed a type I photosensitizer (TTTDM) with an aggregation-induced emission (AIE) property and used F-127 to encapsulate the TTTDM into nanoparticles (F-127 AIE NPs). The NPs exhibit highly efficient ROS generation by enhancing intramolecular D–A interaction and confining molecular non-radiative transitions. Furthermore, the NPs can sufficiently penetrate the biofilm matrix and then detect and eliminate mature bacterial biofilms upon white light irradiation. This strategy holds great promise for the rapid detection and eradication of bacterial biofilms.https://www.mdpi.com/1420-3049/28/14/5368aggregation-induced emissiontype I photosensitizerbiofilmbacterial imaginganti-biofilm materials |
| spellingShingle | Jinghong Shi Yucheng Wang Wei He Ziyue Ye Mengli Liu Zheng Zhao Jacky Wing Yip Lam Pengfei Zhang Ryan Tsz Kin Kwok Ben Zhong Tang Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm Molecules aggregation-induced emission type I photosensitizer biofilm bacterial imaging anti-biofilm materials |
| title | Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm |
| title_full | Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm |
| title_fullStr | Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm |
| title_full_unstemmed | Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm |
| title_short | Precise Molecular Engineering of Type I Photosensitizer with Aggregation-Induced Emission for Image-Guided Photodynamic Eradication of Biofilm |
| title_sort | precise molecular engineering of type i photosensitizer with aggregation induced emission for image guided photodynamic eradication of biofilm |
| topic | aggregation-induced emission type I photosensitizer biofilm bacterial imaging anti-biofilm materials |
| url | https://www.mdpi.com/1420-3049/28/14/5368 |
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