What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis?
The identification of biomarkers that help identify individuals at imminent risk of progression to rheumatoid arthritis (RA) is of crucial importance for disease prevention. In recent years, several studies have highlighted the value of musculoskeletal (MSK) ultrasound (US) in predicting progression...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Healthcare |
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| Online Access: | https://www.mdpi.com/2227-9032/9/6/752 |
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| author | Andrea Di Matteo Davide Corradini Kulveer Mankia |
| author_facet | Andrea Di Matteo Davide Corradini Kulveer Mankia |
| author_sort | Andrea Di Matteo |
| collection | DOAJ |
| description | The identification of biomarkers that help identify individuals at imminent risk of progression to rheumatoid arthritis (RA) is of crucial importance for disease prevention. In recent years, several studies have highlighted the value of musculoskeletal (MSK) ultrasound (US) in predicting progression to inflammatory arthritis (IA) in individuals ‘at-risk’ of RA. These studies have highlighted the following main aspects: first, in RA-related autoantibody-positive individuals, MSK symptoms seem to develop before ‘sub-clinical’ joint inflammation occurs on US. Second, the detection of ‘sub-clinical’ synovitis (and/or bone erosions) greatly increases the risk of IA development in these ‘at-risk’ individuals. US has a potential key role for better understanding the ‘pre-clinical’ stages in individuals ‘at-risk’ of RA, and for the early identification of those individuals at high risk of developing IA. Further research is needed to address questions on image analysis and standardization. In this review, we provide an overview of the most relevant studies which have investigated the value of US in the prediction of RA development in individuals ‘at-risk’ of RA who have MSK symptoms, but no clinical evidence of IA. We highlight recent insights, limitations, and future perspectives of US use in this important population. |
| first_indexed | 2024-03-10T10:17:49Z |
| format | Article |
| id | doaj.art-aabb74f1fb9842fe9fefd077bc84d46e |
| institution | Directory Open Access Journal |
| issn | 2227-9032 |
| language | English |
| last_indexed | 2024-03-10T10:17:49Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Healthcare |
| spelling | doaj.art-aabb74f1fb9842fe9fefd077bc84d46e2023-11-22T00:41:46ZengMDPI AGHealthcare2227-90322021-06-019675210.3390/healthcare9060752What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis?Andrea Di Matteo0Davide Corradini1Kulveer Mankia2Rheumatology Unit, Department of Clinical and Molecular Sciences, Polytechnic University of Marche, “Carlo Urbani” Hospital, Jesi, 60035 Ancona, ItalyRheumatology Unit, University of Cagliari and AOU University Clinic of Cagliari, 09042 Monserrato, ItalyLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds LS74SA, UKThe identification of biomarkers that help identify individuals at imminent risk of progression to rheumatoid arthritis (RA) is of crucial importance for disease prevention. In recent years, several studies have highlighted the value of musculoskeletal (MSK) ultrasound (US) in predicting progression to inflammatory arthritis (IA) in individuals ‘at-risk’ of RA. These studies have highlighted the following main aspects: first, in RA-related autoantibody-positive individuals, MSK symptoms seem to develop before ‘sub-clinical’ joint inflammation occurs on US. Second, the detection of ‘sub-clinical’ synovitis (and/or bone erosions) greatly increases the risk of IA development in these ‘at-risk’ individuals. US has a potential key role for better understanding the ‘pre-clinical’ stages in individuals ‘at-risk’ of RA, and for the early identification of those individuals at high risk of developing IA. Further research is needed to address questions on image analysis and standardization. In this review, we provide an overview of the most relevant studies which have investigated the value of US in the prediction of RA development in individuals ‘at-risk’ of RA who have MSK symptoms, but no clinical evidence of IA. We highlight recent insights, limitations, and future perspectives of US use in this important population.https://www.mdpi.com/2227-9032/9/6/752musculoskeletal ultrasoundpower Doppler signalsynovial hypertrophyprediction‘at-risk’rheumatoid arthritis |
| spellingShingle | Andrea Di Matteo Davide Corradini Kulveer Mankia What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? Healthcare musculoskeletal ultrasound power Doppler signal synovial hypertrophy prediction ‘at-risk’ rheumatoid arthritis |
| title | What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? |
| title_full | What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? |
| title_fullStr | What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? |
| title_full_unstemmed | What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? |
| title_short | What Is the Value of Ultrasound in Individuals ‘At-Risk’ of Rheumatoid Arthritis Who Do Not Have Clinical Synovitis? |
| title_sort | what is the value of ultrasound in individuals at risk of rheumatoid arthritis who do not have clinical synovitis |
| topic | musculoskeletal ultrasound power Doppler signal synovial hypertrophy prediction ‘at-risk’ rheumatoid arthritis |
| url | https://www.mdpi.com/2227-9032/9/6/752 |
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