Mel-CAM Expression in Common Oral Carcinomas
Statement of the Problem: Mel-CAM (CD146, MUC18) is a 113-kD heterophilic cell-cell adhesion glycoprotein found in normal and tumoral tissues. The biologic functions and role of the Mel-CAM can be employed as a diagnostic marker in pathology. Purpose: The aim of this study was assessing the expres...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2020-09-01
|
| Series: | Journal of Dentistry |
| Subjects: | |
| Online Access: | https://dentjods.sums.ac.ir/article_45904_6e2b122a492412c50ed4bb6b89965df1.pdf |
| _version_ | 1811280495678324736 |
|---|---|
| author | Nafise Shamloo Nasim Taghavi Samira Behrad Ali Dehghani Nazhvani |
| author_facet | Nafise Shamloo Nasim Taghavi Samira Behrad Ali Dehghani Nazhvani |
| author_sort | Nafise Shamloo |
| collection | DOAJ |
| description | Statement of the Problem: Mel-CAM (CD146, MUC18) is a 113-kD heterophilic cell-cell adhesion glycoprotein found in normal and tumoral tissues. The biologic functions and role of the Mel-CAM can be employed as a diagnostic marker in pathology.
Purpose: The aim of this study was assessing the expression of Mel-CAM in common oral carcinomas like salivary gland mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC) to differentiate the OSCC from high-grade MEC.
Materials and Method: This study was performed on 19 specimens of MEC and 17 specimens of OSCC, which were retrieved from the archive of Department of Pathology of Taleghani Hospital, Tehran, Iran. Immunohistochemical staining was performed by using antibody against CD146. The data were analyzed using SPSS software through Mann-Whitney, Spearman's correlation coefficient, and Kruskal-Wallis tests.
Results: Mel-CAM was expressed in all MEC samples and 10 OSCC cases. The two groups were significantly different regarding the CD146 expression (p= 0.035). Furthermore, the CD146 expression was found to be significantly correlated with the invasion mode (p= 0.002), tumor size (p= 0.012), and histological grade (p= 0.024) in OSCC group. No significant correlation existed between the expression, intensity, and location with the histological grade of MEC (p> 0.05) nor was any significant correlation detected between the CD146 expression and lymph node metastasis in neither group.
Conclusion: Regarding the significant correlation between the CD146 expression and the prognostic factors in OSCC, this marker may predict the prognosis in OSCC patients, but not the MEC lesions. It cannot be used for differentiating high-grade MEC and OSCC. |
| first_indexed | 2024-04-13T01:15:41Z |
| format | Article |
| id | doaj.art-aabc808428c341249a01f3b349810879 |
| institution | Directory Open Access Journal |
| issn | 2345-6485 2345-6418 |
| language | English |
| last_indexed | 2024-04-13T01:15:41Z |
| publishDate | 2020-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Journal of Dentistry |
| spelling | doaj.art-aabc808428c341249a01f3b3498108792022-12-22T03:08:56ZengShiraz University of Medical SciencesJournal of Dentistry2345-64852345-64182020-09-0121318418910.30476/DENTJODS.2019.77873.0Mel-CAM Expression in Common Oral CarcinomasNafise Shamloo 0Nasim Taghavi 1Samira Behrad 2Ali Dehghani Nazhvani 3Dept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDept. of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, IranDept. of Oral and Maxillofacial Pathology, School of Dentistry, Semnan University of Medical Sciences, Semnan, IranDept. of Oral and Maxillofacial Pathology, Biomaterials Research Center, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, IranStatement of the Problem: Mel-CAM (CD146, MUC18) is a 113-kD heterophilic cell-cell adhesion glycoprotein found in normal and tumoral tissues. The biologic functions and role of the Mel-CAM can be employed as a diagnostic marker in pathology. Purpose: The aim of this study was assessing the expression of Mel-CAM in common oral carcinomas like salivary gland mucoepidermoid carcinoma (MEC) and oral squamous cell carcinoma (OSCC) to differentiate the OSCC from high-grade MEC. Materials and Method: This study was performed on 19 specimens of MEC and 17 specimens of OSCC, which were retrieved from the archive of Department of Pathology of Taleghani Hospital, Tehran, Iran. Immunohistochemical staining was performed by using antibody against CD146. The data were analyzed using SPSS software through Mann-Whitney, Spearman's correlation coefficient, and Kruskal-Wallis tests. Results: Mel-CAM was expressed in all MEC samples and 10 OSCC cases. The two groups were significantly different regarding the CD146 expression (p= 0.035). Furthermore, the CD146 expression was found to be significantly correlated with the invasion mode (p= 0.002), tumor size (p= 0.012), and histological grade (p= 0.024) in OSCC group. No significant correlation existed between the expression, intensity, and location with the histological grade of MEC (p> 0.05) nor was any significant correlation detected between the CD146 expression and lymph node metastasis in neither group. Conclusion: Regarding the significant correlation between the CD146 expression and the prognostic factors in OSCC, this marker may predict the prognosis in OSCC patients, but not the MEC lesions. It cannot be used for differentiating high-grade MEC and OSCC.https://dentjods.sums.ac.ir/article_45904_6e2b122a492412c50ed4bb6b89965df1.pdfmel-cam; mucoepidermoid carcinoma; oral squamous cell carcinoma; salivary glands |
| spellingShingle | Nafise Shamloo Nasim Taghavi Samira Behrad Ali Dehghani Nazhvani Mel-CAM Expression in Common Oral Carcinomas Journal of Dentistry mel-cam; mucoepidermoid carcinoma; oral squamous cell carcinoma; salivary glands |
| title | Mel-CAM Expression in Common Oral Carcinomas |
| title_full | Mel-CAM Expression in Common Oral Carcinomas |
| title_fullStr | Mel-CAM Expression in Common Oral Carcinomas |
| title_full_unstemmed | Mel-CAM Expression in Common Oral Carcinomas |
| title_short | Mel-CAM Expression in Common Oral Carcinomas |
| title_sort | mel cam expression in common oral carcinomas |
| topic | mel-cam; mucoepidermoid carcinoma; oral squamous cell carcinoma; salivary glands |
| url | https://dentjods.sums.ac.ir/article_45904_6e2b122a492412c50ed4bb6b89965df1.pdf |
| work_keys_str_mv | AT nafiseshamloo melcamexpressionincommonoralcarcinomas AT nasimtaghavi melcamexpressionincommonoralcarcinomas AT samirabehrad melcamexpressionincommonoralcarcinomas AT alidehghaninazhvani melcamexpressionincommonoralcarcinomas |