Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis
Background: A corpus callosotomy (CC) is a procedure in which the corpus callosum, the largest collection of commissural fibers in the brain, is disconnected to treat epileptic seizures. The occurrence of chemical meningitis has been reported in association with this procedure. We hypothesized that...
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MDPI AG
2021-05-01
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| Series: | Brain Sciences |
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| author | Ayataka Fujimoto Keisuke Hatano Toshiki Nozaki Keishiro Sato Hideo Enoki Tohru Okanishi |
| author_facet | Ayataka Fujimoto Keisuke Hatano Toshiki Nozaki Keishiro Sato Hideo Enoki Tohru Okanishi |
| author_sort | Ayataka Fujimoto |
| collection | DOAJ |
| description | Background: A corpus callosotomy (CC) is a procedure in which the corpus callosum, the largest collection of commissural fibers in the brain, is disconnected to treat epileptic seizures. The occurrence of chemical meningitis has been reported in association with this procedure. We hypothesized that intraventricular pneumocephalus after CC surgery represents a risk factor for postoperative chemical meningitis. The purpose of this study was to analyze the potential risk factors for postoperative chemical meningitis in patients with medically intractable epilepsy who underwent a CC. Methods: Among the patients who underwent an anterior/total CC for medically intractable epilepsy between January 2009 and March 2021, participants were comprised of those who underwent a computed tomography scan on postoperative day 0. We statistically compared the groups with (c-Group) or without chemical meningitis (nc-Group) to determine the risk factors. Results: Of the 80 patients who underwent a CC, 65 patients (25 females and 40 males) met the inclusion criteria. Their age at the time of their CC procedure was 0–57 years. The c-Group (17%) was comprised of seven females and four males (age at the time of their CC procedure, 1–43 years), and the nc-Group (83%) was comprised of 18 females and 36 males (age at the time of their CC procedure, 0–57 years). Mann–Whitney U-tests (<i>p</i> = 0.002) and univariate logistic regression analysis (<i>p</i> = 0.001) showed a significant difference in pneumocephalus between the groups. Conclusion: Postoperative pneumocephalus identified on a computed tomography scan is a risk factor for post-CC chemical meningitis. |
| first_indexed | 2024-03-10T11:24:11Z |
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| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:24:11Z |
| publishDate | 2021-05-01 |
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| series | Brain Sciences |
| spelling | doaj.art-aabdc87514be4ca0921381736834b7d82023-11-21T19:51:13ZengMDPI AGBrain Sciences2076-34252021-05-0111563810.3390/brainsci11050638Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical MeningitisAyataka Fujimoto0Keisuke Hatano1Toshiki Nozaki2Keishiro Sato3Hideo Enoki4Tohru Okanishi5Comprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanComprehensive Epilepsy Center, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Nakaku, Hamamatsu, Shizuoka 430-8558, JapanBackground: A corpus callosotomy (CC) is a procedure in which the corpus callosum, the largest collection of commissural fibers in the brain, is disconnected to treat epileptic seizures. The occurrence of chemical meningitis has been reported in association with this procedure. We hypothesized that intraventricular pneumocephalus after CC surgery represents a risk factor for postoperative chemical meningitis. The purpose of this study was to analyze the potential risk factors for postoperative chemical meningitis in patients with medically intractable epilepsy who underwent a CC. Methods: Among the patients who underwent an anterior/total CC for medically intractable epilepsy between January 2009 and March 2021, participants were comprised of those who underwent a computed tomography scan on postoperative day 0. We statistically compared the groups with (c-Group) or without chemical meningitis (nc-Group) to determine the risk factors. Results: Of the 80 patients who underwent a CC, 65 patients (25 females and 40 males) met the inclusion criteria. Their age at the time of their CC procedure was 0–57 years. The c-Group (17%) was comprised of seven females and four males (age at the time of their CC procedure, 1–43 years), and the nc-Group (83%) was comprised of 18 females and 36 males (age at the time of their CC procedure, 0–57 years). Mann–Whitney U-tests (<i>p</i> = 0.002) and univariate logistic regression analysis (<i>p</i> = 0.001) showed a significant difference in pneumocephalus between the groups. Conclusion: Postoperative pneumocephalus identified on a computed tomography scan is a risk factor for post-CC chemical meningitis.https://www.mdpi.com/2076-3425/11/5/638corpus callosotomychemical meningitispneumocephalushigh feverrisk factor |
| spellingShingle | Ayataka Fujimoto Keisuke Hatano Toshiki Nozaki Keishiro Sato Hideo Enoki Tohru Okanishi Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis Brain Sciences corpus callosotomy chemical meningitis pneumocephalus high fever risk factor |
| title | Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis |
| title_full | Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis |
| title_fullStr | Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis |
| title_full_unstemmed | Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis |
| title_short | Postoperative Pneumocephalus on Computed Tomography Might Predict Post-Corpus Callosotomy Chemical Meningitis |
| title_sort | postoperative pneumocephalus on computed tomography might predict post corpus callosotomy chemical meningitis |
| topic | corpus callosotomy chemical meningitis pneumocephalus high fever risk factor |
| url | https://www.mdpi.com/2076-3425/11/5/638 |
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