Biological Properties and Probiotic Potential of Intestinal Lactobacilli
Data on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactoba...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Scientific Сentre for Family Health and Human Reproduction Problems
2019-04-01
|
| Series: | Acta Biomedica Scientifica |
| Subjects: | |
| Online Access: | https://www.actabiomedica.ru/jour/article/view/1989 |
| _version_ | 1826853355168727040 |
|---|---|
| author | Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova |
| author_facet | Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova |
| author_sort | Ekaterina A. Borovkova |
| collection | DOAJ |
| description | Data on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactobacilli and enterococci). However, publications about effectiveness of autoprobiotic therapy are few and contradictory.The aim of the study was to investigate the biological properties and probiotic potential of intestinal lactobacilli, as well as the effectiveness of autoprobiotic therapy, based on Lactobacillus spp.Methods. Biological properties (antibiotic resistance, hemolytic, adhesive and antagonistic activity) were studied in 159 strains of intestinal lactobacilli. Autoprobiotic therapy with sour-milk ferments based on lactobacilli autostrains was carried out in 78 patients of the of the North Caucasus Federal District (NCFD) hospitals to correct the microbiocenosis of the large intestine due to antibiotic therapy.Results. The indigene strains of the intestinal lactobacilli of patients of NCFD hospitals are characterized by a wide spectrum of antibiotic sensitivity, lack of hemolysin production, medium adhesiveness and a high degree of antagonistic activity. Autoprobiotic therapy using Lactobacillus spp. significantly increases the amount of lactobacilli of the large intestine of patients in hospitals of the North Caucasian Federal District.Conclusion. A high probiotic potential of the indigenous intestinal lactobacilli is identified, which makes it possible to use them as effective autoprobiotics. The effectiveness of autoprobiotics with fermented milk starters with Lactobacillus spp. has been proven to restore the normal amount of intestinal lactobacilli patients after the use of broad-spectrum antibiotics. |
| first_indexed | 2024-03-08T12:17:16Z |
| format | Article |
| id | doaj.art-aabe2f8186e2460ba214139df36c9e0a |
| institution | Directory Open Access Journal |
| issn | 2541-9420 2587-9596 |
| language | Russian |
| last_indexed | 2025-02-16T17:24:04Z |
| publishDate | 2019-04-01 |
| publisher | Scientific Сentre for Family Health and Human Reproduction Problems |
| record_format | Article |
| series | Acta Biomedica Scientifica |
| spelling | doaj.art-aabe2f8186e2460ba214139df36c9e0a2025-01-27T16:48:54ZrusScientific Сentre for Family Health and Human Reproduction ProblemsActa Biomedica Scientifica2541-94202587-95962019-04-014112413210.29413/ABS.2019-4.1.191845Biological Properties and Probiotic Potential of Intestinal LactobacilliEkaterina A. Borovkova0Elena V. Alieva1Tatyana V. Frolova2Stavropol State Medical UniversityStavropol State Medical UniversityKislovodsk City HospitalData on inefficiency in some cases or temporary positive effect of commercial probiotics led to the development of the concept of autoprobiotic therapy. According to this, the correction of disturbed microbiocenoses is carried out using autostrains of indigenous normal flora (bifidobacteria, lactobacilli and enterococci). However, publications about effectiveness of autoprobiotic therapy are few and contradictory.The aim of the study was to investigate the biological properties and probiotic potential of intestinal lactobacilli, as well as the effectiveness of autoprobiotic therapy, based on Lactobacillus spp.Methods. Biological properties (antibiotic resistance, hemolytic, adhesive and antagonistic activity) were studied in 159 strains of intestinal lactobacilli. Autoprobiotic therapy with sour-milk ferments based on lactobacilli autostrains was carried out in 78 patients of the of the North Caucasus Federal District (NCFD) hospitals to correct the microbiocenosis of the large intestine due to antibiotic therapy.Results. The indigene strains of the intestinal lactobacilli of patients of NCFD hospitals are characterized by a wide spectrum of antibiotic sensitivity, lack of hemolysin production, medium adhesiveness and a high degree of antagonistic activity. Autoprobiotic therapy using Lactobacillus spp. significantly increases the amount of lactobacilli of the large intestine of patients in hospitals of the North Caucasian Federal District.Conclusion. A high probiotic potential of the indigenous intestinal lactobacilli is identified, which makes it possible to use them as effective autoprobiotics. The effectiveness of autoprobiotics with fermented milk starters with Lactobacillus spp. has been proven to restore the normal amount of intestinal lactobacilli patients after the use of broad-spectrum antibiotics.https://www.actabiomedica.ru/jour/article/view/1989intestinal lactobacilliantibiotic sensitivityadhesionantagonismautostrainsautoprobiotic therapy |
| spellingShingle | Ekaterina A. Borovkova Elena V. Alieva Tatyana V. Frolova Biological Properties and Probiotic Potential of Intestinal Lactobacilli Acta Biomedica Scientifica intestinal lactobacilli antibiotic sensitivity adhesion antagonism autostrains autoprobiotic therapy |
| title | Biological Properties and Probiotic Potential of Intestinal Lactobacilli |
| title_full | Biological Properties and Probiotic Potential of Intestinal Lactobacilli |
| title_fullStr | Biological Properties and Probiotic Potential of Intestinal Lactobacilli |
| title_full_unstemmed | Biological Properties and Probiotic Potential of Intestinal Lactobacilli |
| title_short | Biological Properties and Probiotic Potential of Intestinal Lactobacilli |
| title_sort | biological properties and probiotic potential of intestinal lactobacilli |
| topic | intestinal lactobacilli antibiotic sensitivity adhesion antagonism autostrains autoprobiotic therapy |
| url | https://www.actabiomedica.ru/jour/article/view/1989 |
| work_keys_str_mv | AT ekaterinaaborovkova biologicalpropertiesandprobioticpotentialofintestinallactobacilli AT elenavalieva biologicalpropertiesandprobioticpotentialofintestinallactobacilli AT tatyanavfrolova biologicalpropertiesandprobioticpotentialofintestinallactobacilli |