Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M<sup>pro</sup>)

Clean Grinding Technique: A Facile Synthesis and In Silico Antiviral Activity of Hydrazones, Pyrazoles, and Pyrazines Bearing Thiazole Moiety against SARS-CoV-2 Main Protease (M<sup>pro</sup>)

A novel series of some hydrazones bearing thiazole moiety were generated via solvent-drop grinding of thiazole carbohydrazide <b>2</b> with various carbonyl compounds. Also, dehydrative-cyclocondensation of <b>2</b> with active methylene compounds or anhydrides gave the respe...

Повний опис

Бібліографічні деталі
Автори: Sraa Abu-Melha, Mastoura M. Edrees, Sayed M. Riyadh, Mohamad R. Abdelaziz, Abdo A. Elfiky, Sobhi M. Gomha
Формат: Стаття
Мова:English
Опубліковано: MDPI AG 2020-10-01
Серія:Molecules
Предмети:
hydrazide
hydrazone
condensation
cyclo-condensation
docking
SARS-CoV-2 M<sup>pro</sup>
Онлайн доступ:https://www.mdpi.com/1420-3049/25/19/4565

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https://www.mdpi.com/1420-3049/25/19/4565

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