Neural stem cell–derived exosomes regulate cell proliferation, migration, and cell death of brain microvascular endothelial cells via the miR‐9/Hes1 axis under hypoxia

Neural stem cell–derived exosomes regulate cell proliferation, migration, and cell death of brain microvascular endothelial cells via the miR‐9/Hes1 axis under hypoxia

Abstract Background Our previous study found that mouse embryonic neural stem cell (NSC)–derived exosomes (EXOs) regulated NSC differentiation via the miR‐9/Hes1 axis. However, the effects of EXOs on brain microvascular endothelial cell (BMEC) dysfunction via the miR‐9/Hes1 axis remain unknown. Ther...

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Bibliographic Details
Main Authors: Xiaojun Deng, Xiaoyi Hu, Shang Wang, Hui Zhao, Yaqin Wei, Jiaqi Fu, Wenhui Wu, Jinming Liu, Caicai Zhang, Lili Wang, Ping Yuan
Format: Article
Language:English
Published: Wiley 2024-02-01
Series:Animal Models and Experimental Medicine
Subjects:
brain microvascular endothelial cells
exosomes
Hes1
miR‐9
neural stem cells
Online Access:https://doi.org/10.1002/ame2.12394

Internet

https://doi.org/10.1002/ame2.12394

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