Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility
Xueyuan Zhou, Yan Li, Jun Chen, Zhou Fang, Wei Kong, Ji Wen, Qiyao Zhang Reproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of ChinaCorrespondence: Ji Wen; Qiyao Zhang, Reproductive Medical Ce...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-12-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/impact-of-transcutaneous-electrical-acupoint-stimulation-on-bdnf-expre-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1797401164858261504 |
|---|---|
| author | Zhou X Li Y Chen J Fang Z Kong W Wen J Zhang Q |
| author_facet | Zhou X Li Y Chen J Fang Z Kong W Wen J Zhang Q |
| author_sort | Zhou X |
| collection | DOAJ |
| description | Xueyuan Zhou, Yan Li, Jun Chen, Zhou Fang, Wei Kong, Ji Wen, Qiyao Zhang Reproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of ChinaCorrespondence: Ji Wen; Qiyao Zhang, Reproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China, Tel +86 531-82436297, Email 72050580@sdutcm.edu.cn; qiyaozh@163.comPurpose: Transcutaneous electrical acupoint stimulation (TEAS) can be used in patients with infertility. This study explored the impact of TEAS on brain-derived neurotrophic factor (BDNF) levels and in-vitro fertilization (IVF) outcomes in patients with infertility.Patients and Methods: This quasi-experimental study included infertile women undergoing IVF and embryo transfer (IVF-ET) at one hospital between January 2018 and December 2021. The TEAS group received TEAS before IVF, while the placebo group received mock stimulation. The primary outcomes were serum and follicular fluid (FF) BDNF expression levels. Finally, 510 and 518 participants were included in TEAS and placebo groups.Results: The serum (P< 0.001) and FF (P< 0.001) BDNF expression levels were higher in the TEAS group than in the placebo group. The TEAS group had a lower total dose of gonadotropins (P=0.007), higher fertilization rates (P=0.006), higher high-quality embryo rates (P=0.013), and higher pregnancy rates per ET (P=0.031). The subgroup analysis showed that the Val/Val genotype was associated with the differences in serum and FF BDNF between the TEAS and placebo groups (all P< 0.05).Conclusion: In conclusion, TEAS might increase serum and FF BDNF expression levels and improve IVF embryological and clinical outcomes. Patients with the Val/Val genotype might be more likely to benefit from TEAS.Keywords: transcutaneous electrical acupoint stimulation, brain-derived neurotrophic factor, infertility, in-vitro fertilization, embryo transfer, quasi-experimental study |
| first_indexed | 2024-03-09T02:05:54Z |
| format | Article |
| id | doaj.art-aac1ffd71d844c258b40ffdaefefd087 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-03-09T02:05:54Z |
| publishDate | 2023-12-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-aac1ffd71d844c258b40ffdaefefd0872023-12-07T18:03:42ZengDove Medical PressInternational Journal of General Medicine1178-70742023-12-01Volume 165751576288841Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with InfertilityZhou XLi YChen JFang ZKong WWen JZhang QXueyuan Zhou, Yan Li, Jun Chen, Zhou Fang, Wei Kong, Ji Wen, Qiyao Zhang Reproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of ChinaCorrespondence: Ji Wen; Qiyao Zhang, Reproductive Medical Center, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, 250000, People’s Republic of China, Tel +86 531-82436297, Email 72050580@sdutcm.edu.cn; qiyaozh@163.comPurpose: Transcutaneous electrical acupoint stimulation (TEAS) can be used in patients with infertility. This study explored the impact of TEAS on brain-derived neurotrophic factor (BDNF) levels and in-vitro fertilization (IVF) outcomes in patients with infertility.Patients and Methods: This quasi-experimental study included infertile women undergoing IVF and embryo transfer (IVF-ET) at one hospital between January 2018 and December 2021. The TEAS group received TEAS before IVF, while the placebo group received mock stimulation. The primary outcomes were serum and follicular fluid (FF) BDNF expression levels. Finally, 510 and 518 participants were included in TEAS and placebo groups.Results: The serum (P< 0.001) and FF (P< 0.001) BDNF expression levels were higher in the TEAS group than in the placebo group. The TEAS group had a lower total dose of gonadotropins (P=0.007), higher fertilization rates (P=0.006), higher high-quality embryo rates (P=0.013), and higher pregnancy rates per ET (P=0.031). The subgroup analysis showed that the Val/Val genotype was associated with the differences in serum and FF BDNF between the TEAS and placebo groups (all P< 0.05).Conclusion: In conclusion, TEAS might increase serum and FF BDNF expression levels and improve IVF embryological and clinical outcomes. Patients with the Val/Val genotype might be more likely to benefit from TEAS.Keywords: transcutaneous electrical acupoint stimulation, brain-derived neurotrophic factor, infertility, in-vitro fertilization, embryo transfer, quasi-experimental studyhttps://www.dovepress.com/impact-of-transcutaneous-electrical-acupoint-stimulation-on-bdnf-expre-peer-reviewed-fulltext-article-IJGMtranscutaneous electrical acupoint stimulationbrain-derived neurotrophic factorinfertilityin-vitro fertilizationembryo transferquasi-experimental study |
| spellingShingle | Zhou X Li Y Chen J Fang Z Kong W Wen J Zhang Q Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility International Journal of General Medicine transcutaneous electrical acupoint stimulation brain-derived neurotrophic factor infertility in-vitro fertilization embryo transfer quasi-experimental study |
| title | Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility |
| title_full | Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility |
| title_fullStr | Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility |
| title_full_unstemmed | Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility |
| title_short | Impact of Transcutaneous Electrical Acupoint Stimulation on BDNF Expression and IVF Outcomes in Patients with Infertility |
| title_sort | impact of transcutaneous electrical acupoint stimulation on bdnf expression and ivf outcomes in patients with infertility |
| topic | transcutaneous electrical acupoint stimulation brain-derived neurotrophic factor infertility in-vitro fertilization embryo transfer quasi-experimental study |
| url | https://www.dovepress.com/impact-of-transcutaneous-electrical-acupoint-stimulation-on-bdnf-expre-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT zhoux impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT liy impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT chenj impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT fangz impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT kongw impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT wenj impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility AT zhangq impactoftranscutaneouselectricalacupointstimulationonbdnfexpressionandivfoutcomesinpatientswithinfertility |