Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy
Bisphosphonate-related osteonecrosis of the jaws is characterized by alveolar bone exposure, especially after mucosal trauma or after surgical procedures, in patients who have previously received or who are currently receiving bisphosphonates without a history of radiation therapy in the maxillofaci...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Editorial Ciencias Médicas
2014-05-01
|
| Series: | Revista Cubana de Estomatología |
| Subjects: | |
| Online Access: | http://www.revestomatologia.sld.cu/index.php/est/article/view/19 |
| _version_ | 1828907431488389120 |
|---|---|
| author | Juliana Dreyer Menezes Nicole Mello Rahde Fernanda Gonçalves Salum Maria Antonia Figueiredo Karen Cherubini |
| author_facet | Juliana Dreyer Menezes Nicole Mello Rahde Fernanda Gonçalves Salum Maria Antonia Figueiredo Karen Cherubini |
| author_sort | Juliana Dreyer Menezes |
| collection | DOAJ |
| description | Bisphosphonate-related osteonecrosis of the jaws is characterized by alveolar bone exposure, especially after mucosal trauma or after surgical procedures, in patients who have previously received or who are currently receiving bisphosphonates without a history of radiation therapy in the maxillofacial region. The condition is refractory to treatment, and attempts at debridement are not completely effective in eradicating the necrotic bone. We report here a case of a severe osteonecrosis of the jaws in a 77-year-old male patient, who had been subjected to chemotherapy and treatment with zoledronic acid and corticosteroid. The patient also had comorbidities such as diabetes and periodontal disease, which might have contributed to the lesion development. Bisphosphonate-related osteonecrosis of the jaws has become a reality in dental clinical practice. Although palliative treatment aiming at controlling pain, infection and injury progression is indicated, the therapeutic strategy is still challenging. So far, the best approach available is prevention, based on oral care before, during, and after bisphosphonate therapy. |
| first_indexed | 2024-12-13T17:52:28Z |
| format | Article |
| id | doaj.art-aac20cf5eff84c8e87d96c1c63d2abe8 |
| institution | Directory Open Access Journal |
| issn | 0034-7507 1561-297X |
| language | English |
| last_indexed | 2024-12-13T17:52:28Z |
| publishDate | 2014-05-01 |
| publisher | Editorial Ciencias Médicas |
| record_format | Article |
| series | Revista Cubana de Estomatología |
| spelling | doaj.art-aac20cf5eff84c8e87d96c1c63d2abe82022-12-21T23:36:27ZengEditorial Ciencias MédicasRevista Cubana de Estomatología0034-75071561-297X2014-05-01511727759Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapyJuliana Dreyer Menezes0Nicole Mello Rahde1Fernanda Gonçalves Salum2Maria Antonia Figueiredo3Karen Cherubini4Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RSPontifical Catholic University of Rio Grande do Sul, Porto Alegre, RSPontifical Catholic University of Rio Grande do Sul, Porto Alegre, RSPontifical Catholic University of Rio Grande do Sul, Porto Alegre, RSPontifical Catholic University of Rio Grande do Sul, Porto Alegre, RSBisphosphonate-related osteonecrosis of the jaws is characterized by alveolar bone exposure, especially after mucosal trauma or after surgical procedures, in patients who have previously received or who are currently receiving bisphosphonates without a history of radiation therapy in the maxillofacial region. The condition is refractory to treatment, and attempts at debridement are not completely effective in eradicating the necrotic bone. We report here a case of a severe osteonecrosis of the jaws in a 77-year-old male patient, who had been subjected to chemotherapy and treatment with zoledronic acid and corticosteroid. The patient also had comorbidities such as diabetes and periodontal disease, which might have contributed to the lesion development. Bisphosphonate-related osteonecrosis of the jaws has become a reality in dental clinical practice. Although palliative treatment aiming at controlling pain, infection and injury progression is indicated, the therapeutic strategy is still challenging. So far, the best approach available is prevention, based on oral care before, during, and after bisphosphonate therapy.http://www.revestomatologia.sld.cu/index.php/est/article/view/19osteonecrosisbisfosfonatosremodelado óseoenfermedades de los maxilares. |
| spellingShingle | Juliana Dreyer Menezes Nicole Mello Rahde Fernanda Gonçalves Salum Maria Antonia Figueiredo Karen Cherubini Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy Revista Cubana de Estomatología osteonecrosis bisfosfonatos remodelado óseo enfermedades de los maxilares. |
| title | Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| title_full | Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| title_fullStr | Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| title_full_unstemmed | Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| title_short | Severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| title_sort | severe osteonecrosis of the jaws in a compromised patient subjected to bisphosphonate therapy |
| topic | osteonecrosis bisfosfonatos remodelado óseo enfermedades de los maxilares. |
| url | http://www.revestomatologia.sld.cu/index.php/est/article/view/19 |
| work_keys_str_mv | AT julianadreyermenezes severeosteonecrosisofthejawsinacompromisedpatientsubjectedtobisphosphonatetherapy AT nicolemellorahde severeosteonecrosisofthejawsinacompromisedpatientsubjectedtobisphosphonatetherapy AT fernandagoncalvessalum severeosteonecrosisofthejawsinacompromisedpatientsubjectedtobisphosphonatetherapy AT mariaantoniafigueiredo severeosteonecrosisofthejawsinacompromisedpatientsubjectedtobisphosphonatetherapy AT karencherubini severeosteonecrosisofthejawsinacompromisedpatientsubjectedtobisphosphonatetherapy |