p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies
The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/13/12/2885 |
| _version_ | 1797530818250276864 |
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| author | Anđela Horvat Ana Tadijan Ignacija Vlašić Neda Slade |
| author_facet | Anđela Horvat Ana Tadijan Ignacija Vlašić Neda Slade |
| author_sort | Anđela Horvat |
| collection | DOAJ |
| description | The p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing, generating multiple isoforms. The resulting isoforms have important roles in carcinogenesis, while their expression is dysregulated in several human tumors including colorectal carcinoma, which makes them potential targets in cancer treatment. Their activities arise, at least in part, from the ability to form tetramers that bind to specific DNA sequences and activate the transcription of target genes. In this review, we summarize the current understanding of the biological activities and regulation of the p53/p73 isoforms, highlighting their role in colorectal tumorigenesis. The analysis of the expression patterns of the p53/p73 isoforms in human cancers provides an important step in the improvement of cancer therapy. Furthermore, the interactions among the p53 family members which could modulate normal functions of the canonical p53 in tumor tissue are described. Lastly, we emphasize the importance of clinical studies to assess the significance of combining the deregulation of different members of the p53 family to define the outcome of the disease. |
| first_indexed | 2024-03-10T10:35:25Z |
| format | Article |
| id | doaj.art-aac2537461c54e09ac2df8adc2a48c84 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T10:35:25Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-aac2537461c54e09ac2df8adc2a48c842023-11-21T23:22:18ZengMDPI AGCancers2072-66942021-06-011312288510.3390/cancers13122885p53/p73 Protein Network in Colorectal Cancer and Other Human MalignanciesAnđela Horvat0Ana Tadijan1Ignacija Vlašić2Neda Slade3Laboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, CroatiaLaboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, CroatiaLaboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, CroatiaLaboratory for Protein Dynamics, Division of Molecular Medicine, Ruđer Bošković Institute, Bijenička 54, 10000 Zagreb, CroatiaThe p53 tumor suppressor protein is crucial for cell growth control and the maintenance of genomic stability. Later discovered, p63 and p73 share structural and functional similarity with p53. To understand the p53 pathways more profoundly, all family members should be considered. Each family member possesses two promoters and alternative translation initiation sites, and they undergo alternative splicing, generating multiple isoforms. The resulting isoforms have important roles in carcinogenesis, while their expression is dysregulated in several human tumors including colorectal carcinoma, which makes them potential targets in cancer treatment. Their activities arise, at least in part, from the ability to form tetramers that bind to specific DNA sequences and activate the transcription of target genes. In this review, we summarize the current understanding of the biological activities and regulation of the p53/p73 isoforms, highlighting their role in colorectal tumorigenesis. The analysis of the expression patterns of the p53/p73 isoforms in human cancers provides an important step in the improvement of cancer therapy. Furthermore, the interactions among the p53 family members which could modulate normal functions of the canonical p53 in tumor tissue are described. Lastly, we emphasize the importance of clinical studies to assess the significance of combining the deregulation of different members of the p53 family to define the outcome of the disease.https://www.mdpi.com/2072-6694/13/12/2885p53 isoformsp73 isoformscolorectal cancerp53 familyisoform crosstalk |
| spellingShingle | Anđela Horvat Ana Tadijan Ignacija Vlašić Neda Slade p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies Cancers p53 isoforms p73 isoforms colorectal cancer p53 family isoform crosstalk |
| title | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies |
| title_full | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies |
| title_fullStr | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies |
| title_full_unstemmed | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies |
| title_short | p53/p73 Protein Network in Colorectal Cancer and Other Human Malignancies |
| title_sort | p53 p73 protein network in colorectal cancer and other human malignancies |
| topic | p53 isoforms p73 isoforms colorectal cancer p53 family isoform crosstalk |
| url | https://www.mdpi.com/2072-6694/13/12/2885 |
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