FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy

Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programm...

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Bibliographic Details
Main Authors: Jae Hong Im, Jon N. Buzzelli, Keaton Jones, Fanny Franchini, Alex Gordon-Weeks, Bostjan Markelc, Jianzhou Chen, Jin Kim, Yunhong Cao, Ruth J. Muschel
Format: Article
Language:English
Published: Nature Portfolio 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17914-x
Description
Summary:Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy.
ISSN:2041-1723

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