FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy
Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programm...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17914-x |
| _version_ | 1818894465270546432 |
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| author | Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel |
| author_facet | Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel |
| author_sort | Jae Hong Im |
| collection | DOAJ |
| description | Macrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy. |
| first_indexed | 2024-12-19T18:28:55Z |
| format | Article |
| id | doaj.art-aac2c94a42384be185bf6c4fce5f6dff |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T18:28:55Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aac2c94a42384be185bf6c4fce5f6dff2022-12-21T20:10:47ZengNature PortfolioNature Communications2041-17232020-08-0111111410.1038/s41467-020-17914-xFGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapyJae Hong Im0Jon N. Buzzelli1Keaton Jones2Fanny Franchini3Alex Gordon-Weeks4Bostjan Markelc5Jianzhou Chen6Jin Kim7Yunhong Cao8Ruth J. Muschel9Oxford Institute for Radiation Oncology, University of OxfordOxford Institute for Radiation Oncology, University of OxfordOxford Institute for Radiation Oncology, University of OxfordThe Kennedy Institute of RheumatologyNuffield Department of Surgical Sciences, University of OxfordOxford Institute for Radiation Oncology, University of OxfordOxford Institute for Radiation Oncology, University of OxfordGalaxy BiotechOxford Institute for Radiation Oncology, University of OxfordOxford Institute for Radiation Oncology, University of OxfordMacrophages contribute to tumour progression and response to therapy. Here, the authors show that absence of FGF2 in the tumour microenvironment reduces tumour growth and enhances the anti-tumour immune response by altering macrophage polarization. As a result, disruption of this macrophage programming by anti-FGF2 blocking antibodies enhances the outcome from radiotherapy.https://doi.org/10.1038/s41467-020-17914-x |
| spellingShingle | Jae Hong Im Jon N. Buzzelli Keaton Jones Fanny Franchini Alex Gordon-Weeks Bostjan Markelc Jianzhou Chen Jin Kim Yunhong Cao Ruth J. Muschel FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy Nature Communications |
| title | FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy |
| title_full | FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy |
| title_fullStr | FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy |
| title_full_unstemmed | FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy |
| title_short | FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy |
| title_sort | fgf2 alters macrophage polarization tumour immunity and growth and can be targeted during radiotherapy |
| url | https://doi.org/10.1038/s41467-020-17914-x |
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