Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A
Bloodstream infections in low- and middle-income countries (LMICs) are most frequently attributed to invasive Salmonella disease caused by four primary serovars of <i>Salmonella</i> enterica: Typhi, Paratyphi A, Typhimurium, and Enteritidis. We showed previously that a bivalent vaccine t...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/11/1671 |
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| author | Emily M. Boerth Joyce Gong Becky Roffler Claudette M. Thompson Boni Song Sasha F. Malley Angelika Hirsch Calman A. MacLennan Fan Zhang Richard Malley Ying-Jie Lu |
| author_facet | Emily M. Boerth Joyce Gong Becky Roffler Claudette M. Thompson Boni Song Sasha F. Malley Angelika Hirsch Calman A. MacLennan Fan Zhang Richard Malley Ying-Jie Lu |
| author_sort | Emily M. Boerth |
| collection | DOAJ |
| description | Bloodstream infections in low- and middle-income countries (LMICs) are most frequently attributed to invasive Salmonella disease caused by four primary serovars of <i>Salmonella</i> enterica: Typhi, Paratyphi A, Typhimurium, and Enteritidis. We showed previously that a bivalent vaccine targeting <i>S</i>. Typhi and <i>S</i>. Paratyphi A using a Multiple Antigen-Presenting System (MAPS) induced functional antibodies against <i>S</i>. Typhi and <i>S</i>. Paratyphi. In the current study, we describe the preclinical development of a first candidate quadrivalent combination <i>Salmonella</i> vaccine with the potential to cover all four leading invasive <i>Salmonella</i> serotypes. We showed that the quadrivalent <i>Salmonella</i> MAPS vaccine, containing Vi from <i>S</i>. Typhi, O-specific Polysaccharide (OSP) from <i>S.</i> Paratyphi A, <i>S.</i> Enteritidis and <i>S.</i> Typhimurium, combined with the <i>Salmonella</i>-specific protein SseB, elicits robust and functional antibody responses to each of the components of the vaccine. Our data indicates that the application of MAPS technology to the development of vaccines targeting invasive forms of Salmonella is practical and merits additional consideration. |
| first_indexed | 2024-03-09T16:23:53Z |
| format | Article |
| id | doaj.art-aac55b36e4d74c2fb309acdad01b108d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T16:23:53Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-aac55b36e4d74c2fb309acdad01b108d2023-11-24T15:10:01ZengMDPI AGVaccines2076-393X2023-10-011111167110.3390/vaccines11111671Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi AEmily M. Boerth0Joyce Gong1Becky Roffler2Claudette M. Thompson3Boni Song4Sasha F. Malley5Angelika Hirsch6Calman A. MacLennan7Fan Zhang8Richard Malley9Ying-Jie Lu10Division of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USAEnteric & Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, 500 5th Ave. N, Seattle, WA 98109, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USADivision of Infectious Diseases, Boston Children’s Hospital, Harvard Medical School, Boston, MA 02115, USABloodstream infections in low- and middle-income countries (LMICs) are most frequently attributed to invasive Salmonella disease caused by four primary serovars of <i>Salmonella</i> enterica: Typhi, Paratyphi A, Typhimurium, and Enteritidis. We showed previously that a bivalent vaccine targeting <i>S</i>. Typhi and <i>S</i>. Paratyphi A using a Multiple Antigen-Presenting System (MAPS) induced functional antibodies against <i>S</i>. Typhi and <i>S</i>. Paratyphi. In the current study, we describe the preclinical development of a first candidate quadrivalent combination <i>Salmonella</i> vaccine with the potential to cover all four leading invasive <i>Salmonella</i> serotypes. We showed that the quadrivalent <i>Salmonella</i> MAPS vaccine, containing Vi from <i>S</i>. Typhi, O-specific Polysaccharide (OSP) from <i>S.</i> Paratyphi A, <i>S.</i> Enteritidis and <i>S.</i> Typhimurium, combined with the <i>Salmonella</i>-specific protein SseB, elicits robust and functional antibody responses to each of the components of the vaccine. Our data indicates that the application of MAPS technology to the development of vaccines targeting invasive forms of Salmonella is practical and merits additional consideration.https://www.mdpi.com/2076-393X/11/11/1671SalmonellaMAPS vaccineOSPSseBquadrivalentTyphimurium |
| spellingShingle | Emily M. Boerth Joyce Gong Becky Roffler Claudette M. Thompson Boni Song Sasha F. Malley Angelika Hirsch Calman A. MacLennan Fan Zhang Richard Malley Ying-Jie Lu Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A Vaccines Salmonella MAPS vaccine OSP SseB quadrivalent Typhimurium |
| title | Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A |
| title_full | Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A |
| title_fullStr | Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A |
| title_full_unstemmed | Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A |
| title_short | Induction of Broad Immunity against Invasive Salmonella Disease by a Quadrivalent Combination Salmonella MAPS Vaccine Targeting Salmonella Enterica Serovars Typhimurium, Enteritidis, Typhi, and Paratyphi A |
| title_sort | induction of broad immunity against invasive salmonella disease by a quadrivalent combination salmonella maps vaccine targeting salmonella enterica serovars typhimurium enteritidis typhi and paratyphi a |
| topic | Salmonella MAPS vaccine OSP SseB quadrivalent Typhimurium |
| url | https://www.mdpi.com/2076-393X/11/11/1671 |
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