Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures

Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine. The iPSCs exhibit a preference for lineage differentiation to the donor cell type indicating the existence of memory of origin. Although the intrinsic effect of the donor cell type on differentiation of iPSC...

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Bibliographic Details
Main Authors: Nazir M Khan, Martha Elena Diaz-Hernandez, Samir Chihab, Priyanka Priyadarshani, Pallavi Bhattaram, Luke J Mortensen, Rosa M Guzzo, Hicham Drissi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-01-01
Series:eLife
Subjects:
chondrocytes
transcriptomics
stem cells
Online Access:https://elifesciences.org/articles/83138

Internet

https://elifesciences.org/articles/83138

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