Differential chondrogenic differentiation between iPSC derived from healthy and OA cartilage is associated with changes in epigenetic regulation and metabolic transcriptomic signatures
Induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine. The iPSCs exhibit a preference for lineage differentiation to the donor cell type indicating the existence of memory of origin. Although the intrinsic effect of the donor cell type on differentiation of iPSC...
Main Authors: | Nazir M Khan, Martha Elena Diaz-Hernandez, Samir Chihab, Priyanka Priyadarshani, Pallavi Bhattaram, Luke J Mortensen, Rosa M Guzzo, Hicham Drissi |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-01-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/83138 |
Similar Items
-
pH-sensing G protein-coupled orphan receptor GPR68 is expressed in human cartilage and correlates with degradation of extracellular matrix during OA progression
by: Nazir M. Khan, et al.
Published: (2023-12-01) -
Differences in the intrinsic chondrogenic potential of human mesenchymal stromal cells and iPSC‐derived multipotent cells
by: Shiqi Xiang, et al.
Published: (2022-12-01) -
Uncovering pathways regulating chondrogenic differentiation of CHH fibroblasts
by: Alzbeta Chabronova, et al.
Published: (2021-12-01) -
Collagen X Is Dispensable for Hypertrophic Differentiation and Endochondral Ossification of Human iPSC‐Derived Chondrocytes
by: Takeshi Kamakura, et al.
Published: (2023-05-01) -
Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes
by: Amanda R Dicks, et al.
Published: (2023-02-01)