Antimicrobial Peptides with Anti-<i>Candida</i> Activity
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. <i>Candida albicans</i> remains the prevalent etiologic agent, but the incidence of other species such as <i>Candida parapsilosis&...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/16/9264 |
| _version_ | 1797409759344721920 |
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| author | Aitzol Perez-Rodriguez Elena Eraso Guillermo Quindós Estibaliz Mateo |
| author_facet | Aitzol Perez-Rodriguez Elena Eraso Guillermo Quindós Estibaliz Mateo |
| author_sort | Aitzol Perez-Rodriguez |
| collection | DOAJ |
| description | Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. <i>Candida albicans</i> remains the prevalent etiologic agent, but the incidence of other species such as <i>Candida parapsilosis</i>, <i>Candida glabrata</i> and <i>Candida auris</i> keeps increasing. These pathogens frequently show a reduced susceptibility to commonly used antifungal drugs, including polyenes, triazoles and echinocandins, and the incidence of emerging multi-drug-resistant strains of these species continues to increase. Therefore, the need to search for new molecules that target these pathogenic species in a different manner is now more urgent than ever. Nature is an almost endless source of interesting new molecules that could meet this need. Among these molecules, antimicrobial peptides, present in different sources in nature, possess some advantages over conventional antifungal agents, even with their own drawbacks, and are considered as a promising pharmacological option against a wide range of microbial infections. In this review, we describe 20 antimicrobial peptides from different origins that possess an activity against <i>Candida</i>. |
| first_indexed | 2024-03-09T04:19:16Z |
| format | Article |
| id | doaj.art-aac8c3fe6e1f4d1e9c45f7a63696ac0d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:19:16Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-aac8c3fe6e1f4d1e9c45f7a63696ac0d2023-12-03T13:49:30ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012316926410.3390/ijms23169264Antimicrobial Peptides with Anti-<i>Candida</i> ActivityAitzol Perez-Rodriguez0Elena Eraso1Guillermo Quindós2Estibaliz Mateo3Department of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainDepartment of Immunology, Microbiology and Parasitology, Faculty of Medicine and Nursing, University of the Basque Country (UPV/EHU), 48940 Leioa, SpainMycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is the most usual, presenting a high morbidity and mortality. <i>Candida albicans</i> remains the prevalent etiologic agent, but the incidence of other species such as <i>Candida parapsilosis</i>, <i>Candida glabrata</i> and <i>Candida auris</i> keeps increasing. These pathogens frequently show a reduced susceptibility to commonly used antifungal drugs, including polyenes, triazoles and echinocandins, and the incidence of emerging multi-drug-resistant strains of these species continues to increase. Therefore, the need to search for new molecules that target these pathogenic species in a different manner is now more urgent than ever. Nature is an almost endless source of interesting new molecules that could meet this need. Among these molecules, antimicrobial peptides, present in different sources in nature, possess some advantages over conventional antifungal agents, even with their own drawbacks, and are considered as a promising pharmacological option against a wide range of microbial infections. In this review, we describe 20 antimicrobial peptides from different origins that possess an activity against <i>Candida</i>.https://www.mdpi.com/1422-0067/23/16/9264fungal infectionscandidiasismicrobial resistanceantifungal peptides |
| spellingShingle | Aitzol Perez-Rodriguez Elena Eraso Guillermo Quindós Estibaliz Mateo Antimicrobial Peptides with Anti-<i>Candida</i> Activity International Journal of Molecular Sciences fungal infections candidiasis microbial resistance antifungal peptides |
| title | Antimicrobial Peptides with Anti-<i>Candida</i> Activity |
| title_full | Antimicrobial Peptides with Anti-<i>Candida</i> Activity |
| title_fullStr | Antimicrobial Peptides with Anti-<i>Candida</i> Activity |
| title_full_unstemmed | Antimicrobial Peptides with Anti-<i>Candida</i> Activity |
| title_short | Antimicrobial Peptides with Anti-<i>Candida</i> Activity |
| title_sort | antimicrobial peptides with anti i candida i activity |
| topic | fungal infections candidiasis microbial resistance antifungal peptides |
| url | https://www.mdpi.com/1422-0067/23/16/9264 |
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