Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global coronavirus (COVID-19) pandemic. Although initially viewed as an acute respiratory illness, COVID-19 is clearly a complex multisystemic disease with extensive cardiovascular involvement. Emerging e...
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| Format: | Article |
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MDPI AG
2022-05-01
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| Online Access: | https://www.mdpi.com/2075-1729/12/6/781 |
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| author | Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Alexandra Maștaleru Maria Magdalena Leon-Constantin Cristina Mihaela Ghiciuc Sebastian Romica Cozma Lucia Corina Dima-Cozma Irina Mihaela Esanu Florin Mitu |
| author_facet | Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Alexandra Maștaleru Maria Magdalena Leon-Constantin Cristina Mihaela Ghiciuc Sebastian Romica Cozma Lucia Corina Dima-Cozma Irina Mihaela Esanu Florin Mitu |
| author_sort | Ioana Mădălina Zota |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global coronavirus (COVID-19) pandemic. Although initially viewed as an acute respiratory illness, COVID-19 is clearly a complex multisystemic disease with extensive cardiovascular involvement. Emerging evidence shows that the endothelium plays multiple roles in COVID-19 physiopathology, as both a target organ that can be directly infected by SARS-CoV-2 and a mediator in the subsequent inflammatory and thrombotic cascades. Arterial stiffness is an established marker of cardiovascular disease. The scope of this review is to summarize available data on the acute and long-term consequences of COVID-19 on vascular function. COVID-19 causes early vascular aging and arterial stiffness. Fast, noninvasive bedside assessment of arterial stiffness could optimize risk stratification in acute COVID-19, allowing for early escalation of treatment. Vascular physiology remains impaired at least 12 months after infection with SARS-CoV-2, even in otherwise healthy adults. This raises concerns regarding the extent of arterial remodeling in patients with preexisting vascular disease and the potential development of a persistent, chronic COVID-19 vasculopathy. Long-term follow up on larger cohorts is required to investigate the reversibility of COVID-19-induced vascular changes and their associated prognostic implications. |
| first_indexed | 2024-03-09T23:16:53Z |
| format | Article |
| id | doaj.art-aacbdb0d373f474bb762c617a0bd1e3b |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T23:16:53Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-aacbdb0d373f474bb762c617a0bd1e3b2023-11-23T17:35:18ZengMDPI AGLife2075-17292022-05-0112678110.3390/life12060781Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative ReviewIoana Mădălina Zota0Cristian Stătescu1Radu Andy Sascău2Mihai Roca3Larisa Anghel4Alexandra Maștaleru5Maria Magdalena Leon-Constantin6Cristina Mihaela Ghiciuc7Sebastian Romica Cozma8Lucia Corina Dima-Cozma9Irina Mihaela Esanu10Florin Mitu11Department of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaPharmacology, Clinical Pharmacology and Algeziology, Department of Morpho-Functional Sciences II, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Surgery (II), Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaDepartment of Medical Specialties I, Faculty of Medicine, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iași, RomaniaThe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the ongoing global coronavirus (COVID-19) pandemic. Although initially viewed as an acute respiratory illness, COVID-19 is clearly a complex multisystemic disease with extensive cardiovascular involvement. Emerging evidence shows that the endothelium plays multiple roles in COVID-19 physiopathology, as both a target organ that can be directly infected by SARS-CoV-2 and a mediator in the subsequent inflammatory and thrombotic cascades. Arterial stiffness is an established marker of cardiovascular disease. The scope of this review is to summarize available data on the acute and long-term consequences of COVID-19 on vascular function. COVID-19 causes early vascular aging and arterial stiffness. Fast, noninvasive bedside assessment of arterial stiffness could optimize risk stratification in acute COVID-19, allowing for early escalation of treatment. Vascular physiology remains impaired at least 12 months after infection with SARS-CoV-2, even in otherwise healthy adults. This raises concerns regarding the extent of arterial remodeling in patients with preexisting vascular disease and the potential development of a persistent, chronic COVID-19 vasculopathy. Long-term follow up on larger cohorts is required to investigate the reversibility of COVID-19-induced vascular changes and their associated prognostic implications.https://www.mdpi.com/2075-1729/12/6/781SARS-CoV-2COVID-19arterial stiffnesspulse wave velocitycardiovascular riskendotheliitis |
| spellingShingle | Ioana Mădălina Zota Cristian Stătescu Radu Andy Sascău Mihai Roca Larisa Anghel Alexandra Maștaleru Maria Magdalena Leon-Constantin Cristina Mihaela Ghiciuc Sebastian Romica Cozma Lucia Corina Dima-Cozma Irina Mihaela Esanu Florin Mitu Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review Life SARS-CoV-2 COVID-19 arterial stiffness pulse wave velocity cardiovascular risk endotheliitis |
| title | Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review |
| title_full | Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review |
| title_fullStr | Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review |
| title_full_unstemmed | Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review |
| title_short | Acute and Long-Term Consequences of COVID-19 on Arterial Stiffness—A Narrative Review |
| title_sort | acute and long term consequences of covid 19 on arterial stiffness a narrative review |
| topic | SARS-CoV-2 COVID-19 arterial stiffness pulse wave velocity cardiovascular risk endotheliitis |
| url | https://www.mdpi.com/2075-1729/12/6/781 |
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