Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics
The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde deriva...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2016-09-01
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| Series: | Revista Colombiana de Química |
| Subjects: | |
| Online Access: | http://revistas.unal.edu.co/index.php/rcolquim/article/view/61408 |
| _version_ | 1811306754576744448 |
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| author | Mónica Andrea Gordillo Varela Fabio Zuluaga Manuel Noé Chaur Valencia |
| author_facet | Mónica Andrea Gordillo Varela Fabio Zuluaga Manuel Noé Chaur Valencia |
| author_sort | Mónica Andrea Gordillo Varela |
| collection | DOAJ |
| description | The kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 1H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively. |
| first_indexed | 2024-04-13T08:51:13Z |
| format | Article |
| id | doaj.art-aace61671e21407f9d287909f6322c83 |
| institution | Directory Open Access Journal |
| issn | 0120-2804 2357-3791 |
| language | English |
| last_indexed | 2024-04-13T08:51:13Z |
| publishDate | 2016-09-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista Colombiana de Química |
| spelling | doaj.art-aace61671e21407f9d287909f6322c832022-12-22T02:53:28ZengUniversidad Nacional de ColombiaRevista Colombiana de Química0120-28042357-37912016-09-01453395010.15446/rev.colomb.quim.v45n3.6140844269Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamicsMónica Andrea Gordillo Varela0Fabio Zuluaga1Manuel Noé Chaur Valencia2Grupo de Investigación Síntesis y Mecanismos de Reacción en Química Orgánica (SIMERQO) Departamento de Química, Universidad del ValleGrupo de Investigación Síntesis y Mecanismos de Reacción en Química Orgánica (SIMERQO) Departamento de Química, Universidad del ValleGrupo de Investigación Síntesis y Mecanismos de Reacción en Química Orgánica (SIMERQO) Departamento de Química, Universidad del ValleThe kinetic and thermodynamic selectivity of acylhydrazone formation in dynamic combinatorial libraries (DCL) is described. Competition reactions were generated from hydrazides: isoniazid, 4-nitro-benzohydrazide, 4-dimethylamino-benzohydrazide, and nicotinic hydrazide; as well as the aldehyde derivatives: benzaldehyde and 2-pyridine-carboxaldehyde. The obtained species and the distribution of the DCLs were monitored by 1H-NMR spectroscopy finding that those acylhydrazones containing the 4-dimethylamino-benzohydrazide are both the kinetic and thermodynamic product of their respective libraries. Configurational and coordination dynamics for some of these libraries were also investigated. The obtained results allowed the study of the redistribution of components and the amplification of one or more products using light and metal ions as physical and chemical templates, respectively.http://revistas.unal.edu.co/index.php/rcolquim/article/view/61408dynamic combinatorial chemistryacylhydrazonescoordination and configurational dynamics |
| spellingShingle | Mónica Andrea Gordillo Varela Fabio Zuluaga Manuel Noé Chaur Valencia Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics Revista Colombiana de Química dynamic combinatorial chemistry acylhydrazones coordination and configurational dynamics |
| title | Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics |
| title_full | Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics |
| title_fullStr | Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics |
| title_full_unstemmed | Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics |
| title_short | Acylhydrazone-based dynamic combinatorial libraries: study of the thermodynamic/kinetic evolution, configurational and coordination dynamics |
| title_sort | acylhydrazone based dynamic combinatorial libraries study of the thermodynamic kinetic evolution configurational and coordination dynamics |
| topic | dynamic combinatorial chemistry acylhydrazones coordination and configurational dynamics |
| url | http://revistas.unal.edu.co/index.php/rcolquim/article/view/61408 |
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