Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement
Context: Patients in intensive care units have a high risk of experiencing a pharmacological interaction due to complex pharmacotherapy, severe disease, and comorbidities; increasing the risk of adverse effects of medications. Electronic databases are useful sources to identify drug-drug interaction...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
GarVal Editorial Ltda.
2019-05-01
|
| Series: | Journal of Pharmacy & Pharmacognosy Research |
| Subjects: | |
| Online Access: | http://jppres.com/jppres/pdf/vol7/jppres18.483_7.3.184.pdf |
| _version_ | 1818393118586699776 |
|---|---|
| author | Eduardo A. Ziehl Pia M. Córdova Pola B. Fernández Felipe E. Morales Lorenzo A. Villa |
| author_facet | Eduardo A. Ziehl Pia M. Córdova Pola B. Fernández Felipe E. Morales Lorenzo A. Villa |
| author_sort | Eduardo A. Ziehl |
| collection | DOAJ |
| description | Context: Patients in intensive care units have a high risk of experiencing a pharmacological interaction due to complex pharmacotherapy, severe disease, and comorbidities; increasing the risk of adverse effects of medications. Electronic databases are useful sources to identify drug-drug interactions (DDI), especially when new therapeutic alternatives are added to conventional treatments.
Aim: To identify the frequency and severity of potential drug-drug interactions (pDDIs) in ICU patients using three electronic databases.
Methods: Clinical pharmacists collected data on medication dosage and route of administration, sex, age, length of stay, comorbidities, and APACHE II score using patient records. Micromedex, Medscape, and Lexicomp databases were used to identify and categorize pDDIs. Intensivists confirmed if a pDDI was clinically present. kappa concordance test was utilized as a measure of agreement among databases.
Results: Of the 93 ICU patients studied, pDDIs were identified in 89. A positive incremental relationship was found between number of medications, length of stay, and number of pDDIs. Patients with respiratory pathologies were most predisposed to presenting DDIs. Agreement among databases was mixed. Intensivists confirmed 5% of pDDIs.
Conclusions: Discrepancies among databases and in intensivist judgment highlight a significant information gap in the identification of DDIs. |
| first_indexed | 2024-12-14T05:40:14Z |
| format | Article |
| id | doaj.art-aacf99852d0c47328bed4871925dbdab |
| institution | Directory Open Access Journal |
| issn | 0719-4250 |
| language | English |
| last_indexed | 2024-12-14T05:40:14Z |
| publishDate | 2019-05-01 |
| publisher | GarVal Editorial Ltda. |
| record_format | Article |
| series | Journal of Pharmacy & Pharmacognosy Research |
| spelling | doaj.art-aacf99852d0c47328bed4871925dbdab2022-12-21T23:15:03ZengGarVal Editorial Ltda.Journal of Pharmacy & Pharmacognosy Research0719-42502019-05-0173184192Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreementEduardo A. Ziehl0Pia M. Córdova1Pola B. Fernández2Felipe E. Morales3Lorenzo A. Villa4Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Chile.Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Chile.Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Chile.Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Chile.Departamento de Farmacia, Facultad de Farmacia, Universidad de Concepción, Chile.Context: Patients in intensive care units have a high risk of experiencing a pharmacological interaction due to complex pharmacotherapy, severe disease, and comorbidities; increasing the risk of adverse effects of medications. Electronic databases are useful sources to identify drug-drug interactions (DDI), especially when new therapeutic alternatives are added to conventional treatments. Aim: To identify the frequency and severity of potential drug-drug interactions (pDDIs) in ICU patients using three electronic databases. Methods: Clinical pharmacists collected data on medication dosage and route of administration, sex, age, length of stay, comorbidities, and APACHE II score using patient records. Micromedex, Medscape, and Lexicomp databases were used to identify and categorize pDDIs. Intensivists confirmed if a pDDI was clinically present. kappa concordance test was utilized as a measure of agreement among databases. Results: Of the 93 ICU patients studied, pDDIs were identified in 89. A positive incremental relationship was found between number of medications, length of stay, and number of pDDIs. Patients with respiratory pathologies were most predisposed to presenting DDIs. Agreement among databases was mixed. Intensivists confirmed 5% of pDDIs. Conclusions: Discrepancies among databases and in intensivist judgment highlight a significant information gap in the identification of DDIs.http://jppres.com/jppres/pdf/vol7/jppres18.483_7.3.184.pdfclinical pharmacistdrug interactionsintensive care unit |
| spellingShingle | Eduardo A. Ziehl Pia M. Córdova Pola B. Fernández Felipe E. Morales Lorenzo A. Villa Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement Journal of Pharmacy & Pharmacognosy Research clinical pharmacist drug interactions intensive care unit |
| title | Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement |
| title_full | Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement |
| title_fullStr | Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement |
| title_full_unstemmed | Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement |
| title_short | Drug-drug interactions in an intensive care unit of a tertiary hospital in southern Chile: Evaluating databases agreement |
| title_sort | drug drug interactions in an intensive care unit of a tertiary hospital in southern chile evaluating databases agreement |
| topic | clinical pharmacist drug interactions intensive care unit |
| url | http://jppres.com/jppres/pdf/vol7/jppres18.483_7.3.184.pdf |
| work_keys_str_mv | AT eduardoaziehl drugdruginteractionsinanintensivecareunitofatertiaryhospitalinsouthernchileevaluatingdatabasesagreement AT piamcordova drugdruginteractionsinanintensivecareunitofatertiaryhospitalinsouthernchileevaluatingdatabasesagreement AT polabfernandez drugdruginteractionsinanintensivecareunitofatertiaryhospitalinsouthernchileevaluatingdatabasesagreement AT felipeemorales drugdruginteractionsinanintensivecareunitofatertiaryhospitalinsouthernchileevaluatingdatabasesagreement AT lorenzoavilla drugdruginteractionsinanintensivecareunitofatertiaryhospitalinsouthernchileevaluatingdatabasesagreement |