SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES
Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017. Me...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2021-10-01
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| Series: | Pakistan Armed Forces Medical Journal |
| Subjects: | |
| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/3621/3570 |
| _version_ | 1818837038185578496 |
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| author | Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din |
| author_facet | Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din |
| author_sort | Sumaira Bukhsh |
| collection | DOAJ |
| description | Objective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease.
Study Design: Cross sectional study.
Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017.
Methodology: A total of 43 cases were taken in the study. The Autopsy specimens from the bodies of people dying suddenly of ischemic heart disease were taken into the study. Tissues showing autolytic changes and patients dying with coronary artery disease after corrective procedure like stenting and bypass were excluded.
Results: Out of 43 cases, 35 (81.4%) cases were positive for cluster of differentiation 68 (CD 68), 34 (79%) cases were positive for cluster of differentiation 105 (CD 105) & 36 (83.6) cases were positive for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb).
Conclusion: People who had died of ischemic heart disease have more vulnerable plaque in their coronary arteries as compared to the people who had died of non-ischemic cause. Early recognition of the un-ruptured plaque is important for the treatment strategies. |
| first_indexed | 2024-12-19T03:16:09Z |
| format | Article |
| id | doaj.art-aad0ba78b618452aab0e6cdf52056ff2 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-12-19T03:16:09Z |
| publishDate | 2021-10-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-aad0ba78b618452aab0e6cdf52056ff22022-12-21T20:37:53ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422021-10-0171515481552SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIESSumaira Bukhsh0Samia Nasreen1Hassan Tariq2Syed Salman Ali3Muhammad Umer4Nadeem Zafar5Hafeez Ud Din6Combined Military Hospital Malir/National University of Medical Sciences (NUMS) PakistanCombined Military Hospital/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanCombined Military Hospital Abbottabad/National University of Medical Sciences (NUMS) PakistanPakistan Naval Ship Hospital, Karachi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanArmed Forces Institute of Pathology/National University of Medical Sciences (NUMS) Rawalpindi PakistanObjective: To assess the vulnerability of atherosclerotic plaque in coronary arteries of individuals dying of ischemic heart disease. Study Design: Cross sectional study. Place and Duration of Study: Histopathology department, Combined Military Hospital Lahore, from Nov 2016 to Nov 2017. Methodology: A total of 43 cases were taken in the study. The Autopsy specimens from the bodies of people dying suddenly of ischemic heart disease were taken into the study. Tissues showing autolytic changes and patients dying with coronary artery disease after corrective procedure like stenting and bypass were excluded. Results: Out of 43 cases, 35 (81.4%) cases were positive for cluster of differentiation 68 (CD 68), 34 (79%) cases were positive for cluster of differentiation 105 (CD 105) & 36 (83.6) cases were positive for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Kb). Conclusion: People who had died of ischemic heart disease have more vulnerable plaque in their coronary arteries as compared to the people who had died of non-ischemic cause. Early recognition of the un-ruptured plaque is important for the treatment strategies.https://www.pafmj.org/index.php/PAFMJ/article/view/3621/3570atherosclerotic plaquecluster of differentiation 68cluster of differentiation 105nuclear factor-kappa-light-chainenhancer of activated b cells |
| spellingShingle | Sumaira Bukhsh Samia Nasreen Hassan Tariq Syed Salman Ali Muhammad Umer Nadeem Zafar Hafeez Ud Din SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES Pakistan Armed Forces Medical Journal atherosclerotic plaque cluster of differentiation 68 cluster of differentiation 105 nuclear factor-kappa-light-chainenhancer of activated b cells |
| title | SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES |
| title_full | SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES |
| title_fullStr | SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES |
| title_full_unstemmed | SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES |
| title_short | SUDDEN CARDIAC DEATH: VULNERABILITY OF ATHEROSCLEROTIC PLAQUE IN CORONARY ARTERIES |
| title_sort | sudden cardiac death vulnerability of atherosclerotic plaque in coronary arteries |
| topic | atherosclerotic plaque cluster of differentiation 68 cluster of differentiation 105 nuclear factor-kappa-light-chainenhancer of activated b cells |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/3621/3570 |
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