Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

Myeloid PTP1B deficiency protects against atherosclerosis by improving cholesterol homeostasis through an AMPK-dependent mechanism

Abstract Objective Atherosclerosis is a chronic inflammatory process induced by the influx and entrapment of excess lipoproteins into the intima media of arteries. Previously, our lab demonstrated that systemic PTP1B inhibition protects against atherosclerosis in preclinical LDLR−/− models. Similarl...

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Bibliographic Details
Main Authors: Helk Oliver, Dekeryte Ruta, Dawn Thompson, Sarah Kamli-Salino, Sam Philip, Heather M. Wilson, Nimesh Mody, Mirela Delibegovic
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Translational Medicine
Subjects:
PTP1B
Atherosclerosis
Myeloid cells
Cholesterol metabolism
Online Access:https://doi.org/10.1186/s12967-023-04598-2

Internet

https://doi.org/10.1186/s12967-023-04598-2

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