The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity
PurposeAtropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this stud...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2021.624472/full |
| _version_ | 1818928467486441472 |
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| author | Ziyun Cheng Jianhui Mei Suqi Cao Ran Zhang Jiawei Zhou Yuwen Wang |
| author_facet | Ziyun Cheng Jianhui Mei Suqi Cao Ran Zhang Jiawei Zhou Yuwen Wang |
| author_sort | Ziyun Cheng |
| collection | DOAJ |
| description | PurposeAtropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this study, we investigate the short-term (12,16, and 20 h) and long-term (1, 2, and 4 weeks) effects of 0.01% atropine (i.e., 0.1 mg/ml) on contrast sensitivity (CS) in patients with myopia.MethodsThirty adults (23.33 ± 2.93 years old) with myopia between -1.00 and -6.00 diopters (D), astigmatism of -1.50 D or less, and anisometropia of 1.00 D or less, participated in this prospective, masked, placebo-controlled, randomized study. The participants were randomly assigned to receive 0.01% atropine or polyvinyl alcohol eye drops once nightly to both eyes for four weeks. CS was measured binocularly at baseline and 12, 16, 20 h, 1, 2, and 4 weeks after the first use of the eye drops.ResultsThere was no statistically significant differences of CS found between atropine and placebo-controlled groups in both short-term and long-term. There was no statistically significant interaction effect found between the time and group.ConclusionWe demonstrated no significant deleterious effect of 0.01% atropine on adult myopes’ CS. |
| first_indexed | 2024-12-20T03:29:22Z |
| format | Article |
| id | doaj.art-aad3316cfcb4443f8729b4c8320a4396 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-20T03:29:22Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-aad3316cfcb4443f8729b4c8320a43962022-12-21T19:55:01ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2021-02-011510.3389/fnins.2021.624472624472The Effects of 0.01% Atropine on Adult Myopes’ Contrast SensitivityZiyun ChengJianhui MeiSuqi CaoRan ZhangJiawei ZhouYuwen WangPurposeAtropine at a low concentration is considered a safe and effective treatment to mitigate myopia progression. However, the potential unwanted side effects of administering atropine at a low dose on visual functions other than best corrected visual acuity has not been investigated. In this study, we investigate the short-term (12,16, and 20 h) and long-term (1, 2, and 4 weeks) effects of 0.01% atropine (i.e., 0.1 mg/ml) on contrast sensitivity (CS) in patients with myopia.MethodsThirty adults (23.33 ± 2.93 years old) with myopia between -1.00 and -6.00 diopters (D), astigmatism of -1.50 D or less, and anisometropia of 1.00 D or less, participated in this prospective, masked, placebo-controlled, randomized study. The participants were randomly assigned to receive 0.01% atropine or polyvinyl alcohol eye drops once nightly to both eyes for four weeks. CS was measured binocularly at baseline and 12, 16, 20 h, 1, 2, and 4 weeks after the first use of the eye drops.ResultsThere was no statistically significant differences of CS found between atropine and placebo-controlled groups in both short-term and long-term. There was no statistically significant interaction effect found between the time and group.ConclusionWe demonstrated no significant deleterious effect of 0.01% atropine on adult myopes’ CS.https://www.frontiersin.org/articles/10.3389/fnins.2021.624472/fullatropinecontrast sensitivitymyopia controlvisual perceptionmyopia |
| spellingShingle | Ziyun Cheng Jianhui Mei Suqi Cao Ran Zhang Jiawei Zhou Yuwen Wang The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity Frontiers in Neuroscience atropine contrast sensitivity myopia control visual perception myopia |
| title | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
| title_full | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
| title_fullStr | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
| title_full_unstemmed | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
| title_short | The Effects of 0.01% Atropine on Adult Myopes’ Contrast Sensitivity |
| title_sort | effects of 0 01 atropine on adult myopes contrast sensitivity |
| topic | atropine contrast sensitivity myopia control visual perception myopia |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2021.624472/full |
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