Adult onset Still’s disease: 7 years experience at a tertiary care center from South India
Background: Adult onset Still’s disease (AOSD) is uncommon condition regarding which sparse published data are available from India. Methods: Retrospective study of 6 patients, who presented with pyrexia of unknown origin (PUO) seen over a 7-year period who were diagnosed to have AOSD after a thor...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-10-01
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| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://svimstpt.ap.nic.in/jcsr/oct-dec14_files/2oa414.pdf |
| Summary: | Background: Adult onset Still’s disease (AOSD) is uncommon condition regarding which sparse published data are
available from India.
Methods: Retrospective study of 6 patients, who presented with pyrexia of unknown origin (PUO) seen over a 7-year period who were diagnosed to have AOSD after a thorough work-up.
Results: Their mean age was 24.6 (range 18-38) years; there were four males. Mean duration of symptoms was 7.8 (range 3-5) weeks. In addition to prolonged fever, patients presented with rash, arthropathy, hepato-splenomegaly and peripheral lymphadenopathy. Laboratory evaluation revealed neutrophilic leukocytosis, hepatopathy, serositis, raised serum ferritin levels; anti-nuclear antibody and rheumatoid factor were negative in all. One patient developed acute respiratory distress syndrome and died. The remaining five patients were treated with non-steroidal anti-inflammatory drugs, oral corticosteroids, and hydroxy chloroquine and responded well to treatment.
Conclusions: Increased awareness and a high index of suspicion is required for the diagnosis of AOSD. Though mortality is rare, it may occur due to complications. |
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| ISSN: | 2277-5706 2277-8357 |