Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes
The detection of conserved motifs by pattern recognition receptors is a crucial component of the innate detection of pathogens and danger signals via conserved pattern recognition receptors. Here the authors define a pathway that transfers partially digested material from the phagolysosomal pathway...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30654-4 |
| _version_ | 1811257950066442240 |
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| author | Catherine J. Greene Jenny A. Nguyen Samuel M. Cheung Corey R. Arnold Dale R. Balce Ya Ting Wang Adrian Soderholm Neil McKenna Devin Aggarwal Rhiannon I. Campden Benjamin W. Ewanchuk Herbert W. Virgin Robin M. Yates |
| author_facet | Catherine J. Greene Jenny A. Nguyen Samuel M. Cheung Corey R. Arnold Dale R. Balce Ya Ting Wang Adrian Soderholm Neil McKenna Devin Aggarwal Rhiannon I. Campden Benjamin W. Ewanchuk Herbert W. Virgin Robin M. Yates |
| author_sort | Catherine J. Greene |
| collection | DOAJ |
| description | The detection of conserved motifs by pattern recognition receptors is a crucial component of the innate detection of pathogens and danger signals via conserved pattern recognition receptors. Here the authors define a pathway that transfers partially digested material from the phagolysosomal pathway of macrophages to release at the plasma membrane which is associated with enhanced inflammatory potential, by a process they introduce as eructophagy. |
| first_indexed | 2024-04-12T18:05:29Z |
| format | Article |
| id | doaj.art-aad3618ee90b478e9fda4fac3f0b6287 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T18:05:29Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-aad3618ee90b478e9fda4fac3f0b62872022-12-22T03:22:00ZengNature PortfolioNature Communications2041-17232022-06-0113111710.1038/s41467-022-30654-4Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomesCatherine J. Greene0Jenny A. Nguyen1Samuel M. Cheung2Corey R. Arnold3Dale R. Balce4Ya Ting Wang5Adrian Soderholm6Neil McKenna7Devin Aggarwal8Rhiannon I. Campden9Benjamin W. Ewanchuk10Herbert W. Virgin11Robin M. Yates12Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Pathology and Immunology, Washington University School of MedicineDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of CalgaryDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, University of CalgaryDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, University of CalgaryDepartment of Pathology and Immunology, Washington University School of MedicineDepartment of Biochemistry and Molecular Biology, Cumming School of Medicine, University of CalgaryThe detection of conserved motifs by pattern recognition receptors is a crucial component of the innate detection of pathogens and danger signals via conserved pattern recognition receptors. Here the authors define a pathway that transfers partially digested material from the phagolysosomal pathway of macrophages to release at the plasma membrane which is associated with enhanced inflammatory potential, by a process they introduce as eructophagy.https://doi.org/10.1038/s41467-022-30654-4 |
| spellingShingle | Catherine J. Greene Jenny A. Nguyen Samuel M. Cheung Corey R. Arnold Dale R. Balce Ya Ting Wang Adrian Soderholm Neil McKenna Devin Aggarwal Rhiannon I. Campden Benjamin W. Ewanchuk Herbert W. Virgin Robin M. Yates Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes Nature Communications |
| title | Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| title_full | Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| title_fullStr | Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| title_full_unstemmed | Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| title_short | Macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| title_sort | macrophages disseminate pathogen associated molecular patterns through the direct extracellular release of the soluble content of their phagolysosomes |
| url | https://doi.org/10.1038/s41467-022-30654-4 |
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