The role of IgM-enriched intravenous immunoglobulin in transplantation
After organ transplantation, gamma globulin and intravenous immunoglobulin enriched with IgM are most frequently used in septic shock as early immune-support. If the explanted organ is infected, the transplantation, as a life-saving operation, can be performed if there is no systemic inflammation an...
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| Format: | Article |
| Language: | English |
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Association of medical doctors Sanamed Novi Pazar
2014-01-01
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| Series: | Sanamed |
| Subjects: | |
| Online Access: | http://sanamed.rs/sanamed_pdf/sanamed_9_1/Judit_Szabo.pdf |
| _version_ | 1797281484257624064 |
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| author | Szabó Judit Smudla Anikó Fazakas János |
| author_facet | Szabó Judit Smudla Anikó Fazakas János |
| author_sort | Szabó Judit |
| collection | DOAJ |
| description | After organ transplantation, gamma globulin and intravenous immunoglobulin enriched with IgM are most frequently used in septic shock as early immune-support. If the explanted organ is infected, the transplantation, as a life-saving operation, can be performed if there is no systemic inflammation and the patient receives IgM enriched immunoglobulin prophylaxis during surgery. The period after transplantation can be divided into three parts from the infection point of view: the first month after transplantation, the first sixth months and the following six months. Infections within the first month are basically related to the surgical procedure. Because of the immunosuppressive therapy, the opportunistic and fungal infections are more common during the first sixth months. After this period, the occurrence and the type of infections are similar to that of the non-transplant population except for pulmonary infections. The latter is two to three times more frequent. This is explained by the secondary hypogammaglobulinaemia (lower blood levels of IgM and IgG) which is caused by the steroids but most of mycophenolate mofetil by inhibition of the T and B lymphocyte proliferation. Septic shock develops with a continuing fall of IgM levels. Under these circumstances additional intravenous immunoglobulin therapy with IgM can be lifesaving. Besides, immunoglobulin concentrates with IgM may also be used in the case of viral infections without prophylaxis and/or without etiological therapy such as in the case of West Nile virus infection. As a result of the increase in antibiotic resistance, the application of immunotherapy, including immunoglobulins may become the mainstream in the treatment of septic shoc |
| first_indexed | 2024-03-07T16:58:18Z |
| format | Article |
| id | doaj.art-aad39331772e40ca85b92e8dd70ed0e0 |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-03-07T16:58:18Z |
| publishDate | 2014-01-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-aad39331772e40ca85b92e8dd70ed0e02024-03-03T03:31:09ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712014-01-0191637010.5937/sanamed1401063SThe role of IgM-enriched intravenous immunoglobulin in transplantationSzabó Judit0Smudla Anikó1Fazakas János2Semmelweis University, Department of Transplantation and Surgery, HungarySemmelweis University, Department of Transplantation and Surgery, HungarySemmelweis University, Department of Transplantation and Surgery, HungaryAfter organ transplantation, gamma globulin and intravenous immunoglobulin enriched with IgM are most frequently used in septic shock as early immune-support. If the explanted organ is infected, the transplantation, as a life-saving operation, can be performed if there is no systemic inflammation and the patient receives IgM enriched immunoglobulin prophylaxis during surgery. The period after transplantation can be divided into three parts from the infection point of view: the first month after transplantation, the first sixth months and the following six months. Infections within the first month are basically related to the surgical procedure. Because of the immunosuppressive therapy, the opportunistic and fungal infections are more common during the first sixth months. After this period, the occurrence and the type of infections are similar to that of the non-transplant population except for pulmonary infections. The latter is two to three times more frequent. This is explained by the secondary hypogammaglobulinaemia (lower blood levels of IgM and IgG) which is caused by the steroids but most of mycophenolate mofetil by inhibition of the T and B lymphocyte proliferation. Septic shock develops with a continuing fall of IgM levels. Under these circumstances additional intravenous immunoglobulin therapy with IgM can be lifesaving. Besides, immunoglobulin concentrates with IgM may also be used in the case of viral infections without prophylaxis and/or without etiological therapy such as in the case of West Nile virus infection. As a result of the increase in antibiotic resistance, the application of immunotherapy, including immunoglobulins may become the mainstream in the treatment of septic shochttp://sanamed.rs/sanamed_pdf/sanamed_9_1/Judit_Szabo.pdfimmunoglobulinIgMseptic shocktransplantation |
| spellingShingle | Szabó Judit Smudla Anikó Fazakas János The role of IgM-enriched intravenous immunoglobulin in transplantation Sanamed immunoglobulin IgM septic shock transplantation |
| title | The role of IgM-enriched intravenous immunoglobulin in transplantation |
| title_full | The role of IgM-enriched intravenous immunoglobulin in transplantation |
| title_fullStr | The role of IgM-enriched intravenous immunoglobulin in transplantation |
| title_full_unstemmed | The role of IgM-enriched intravenous immunoglobulin in transplantation |
| title_short | The role of IgM-enriched intravenous immunoglobulin in transplantation |
| title_sort | role of igm enriched intravenous immunoglobulin in transplantation |
| topic | immunoglobulin IgM septic shock transplantation |
| url | http://sanamed.rs/sanamed_pdf/sanamed_9_1/Judit_Szabo.pdf |
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