Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus
Oral lichen planus (OLP) is an inflammatory condition of oral mucosa and skin. The present study compared salivary cortisol, depression and anxiety levels of patients with erosive and reticular OLP and healthy controls. In this case-control trial, 69 individuals (23 healthy, 23 erosive OLP and 23 re...
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| Format: | Article |
| Language: | English |
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EDP Sciences
2023-01-01
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| Series: | Journal of Oral Medicine and Oral Surgery |
| Subjects: | |
| Online Access: | https://www.jomos.org/articles/mbcb/full_html/2023/02/mbcb220179/mbcb220179.html |
| _version_ | 1797843658286825472 |
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| author | Jafari Soudeh Baharvand Maryam Jarahzade Maryam Namdari Mahshid Hojjat Pardis Alimohammadi Marzieh |
| author_facet | Jafari Soudeh Baharvand Maryam Jarahzade Maryam Namdari Mahshid Hojjat Pardis Alimohammadi Marzieh |
| author_sort | Jafari Soudeh |
| collection | DOAJ |
| description | Oral lichen planus (OLP) is an inflammatory condition of oral mucosa and skin. The present study compared salivary cortisol, depression and anxiety levels of patients with erosive and reticular OLP and healthy controls. In this case-control trial, 69 individuals (23 healthy, 23 erosive OLP and 23 reticular OLP patients) were selected. The participants completed the hospital anxiety and depression scale (HADS) and 5 mL of their unstimulated saliva were collected. Salivary cortisol levels were measured by enzyme-linked immunosorbent assay(ELISA). The comparison of anxiety and depression scores as well as salivary cortisol levels was done one-way analysis of variance (ANOVA) test while the paired comparisons were done by Turkey post hoc test. The mean anxiety score in erosive OLP patients was significantly higher than that in the control and reticular OLP groups. The reticular OLP and control groups had no significant difference in this respect. The three groups were not significantly different regarding the depression score or salivary level of cortisol. The correlation between depression and anxiety was significant but salivary level of cortisol had no correlation with anxiety or depression. This study showed that anxiety control may aid in control of erosive OLP, although further investigations are required. |
| first_indexed | 2024-04-09T17:08:55Z |
| format | Article |
| id | doaj.art-aad45bef00f7464dbe51a45b347b2111 |
| institution | Directory Open Access Journal |
| issn | 2608-1326 |
| language | English |
| last_indexed | 2024-04-09T17:08:55Z |
| publishDate | 2023-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Journal of Oral Medicine and Oral Surgery |
| spelling | doaj.art-aad45bef00f7464dbe51a45b347b21112023-04-20T08:28:39ZengEDP SciencesJournal of Oral Medicine and Oral Surgery2608-13262023-01-012921210.1051/mbcb/2023009mbcb220179Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planusJafari Soudeh0Baharvand Maryam1Jarahzade Maryam2Namdari Mahshid3Hojjat Pardis4Alimohammadi Marzieh5https://orcid.org/0000-0002-9183-3977Department of Oral Medicine, Dental School, Shahid Beheshti University of Medical SciencesDepartment of Oral and Maxillofacial Medicine, School of Dentistry, Shahid Beheshti University of Medical SciencesDepartment of Oral Medicine, Dental Faculty, Shahid Beheshti University of Medical SciencesCommunity Oral Health Department, School of Dentistry, Shahid Beheshti University of Medical SciencesDepartment of Periodontics, Faculty of Dentistry, Tehran Medical Sciences, Islamic Azad UniversityDepartment of Oral Medicine, Dental Faculty, Shahid Beheshti University of Medical SciencesOral lichen planus (OLP) is an inflammatory condition of oral mucosa and skin. The present study compared salivary cortisol, depression and anxiety levels of patients with erosive and reticular OLP and healthy controls. In this case-control trial, 69 individuals (23 healthy, 23 erosive OLP and 23 reticular OLP patients) were selected. The participants completed the hospital anxiety and depression scale (HADS) and 5 mL of their unstimulated saliva were collected. Salivary cortisol levels were measured by enzyme-linked immunosorbent assay(ELISA). The comparison of anxiety and depression scores as well as salivary cortisol levels was done one-way analysis of variance (ANOVA) test while the paired comparisons were done by Turkey post hoc test. The mean anxiety score in erosive OLP patients was significantly higher than that in the control and reticular OLP groups. The reticular OLP and control groups had no significant difference in this respect. The three groups were not significantly different regarding the depression score or salivary level of cortisol. The correlation between depression and anxiety was significant but salivary level of cortisol had no correlation with anxiety or depression. This study showed that anxiety control may aid in control of erosive OLP, although further investigations are required.https://www.jomos.org/articles/mbcb/full_html/2023/02/mbcb220179/mbcb220179.htmlanxietydepressionscalesaliva |
| spellingShingle | Jafari Soudeh Baharvand Maryam Jarahzade Maryam Namdari Mahshid Hojjat Pardis Alimohammadi Marzieh Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus Journal of Oral Medicine and Oral Surgery anxiety depression scale saliva |
| title | Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus |
| title_full | Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus |
| title_fullStr | Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus |
| title_full_unstemmed | Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus |
| title_short | Comparative assessment of salivary level of cortisol, anxiety and depression in patients with oral lichen planus |
| title_sort | comparative assessment of salivary level of cortisol anxiety and depression in patients with oral lichen planus |
| topic | anxiety depression scale saliva |
| url | https://www.jomos.org/articles/mbcb/full_html/2023/02/mbcb220179/mbcb220179.html |
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