Comparison of Antimicrobial Efficacy of Triclosan- Containing, Herbal and Homeopathy Toothpastes- An Invitro Study
Background: Use of antimicrobial agents is one of the important strategies to prevent oral diseases. These agents vary in their abilities to deliver preventive and therapeutic benefits. Objectives: This invitro study was conducted to assess antimicrobial efficacy of different toothpastes agains...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/6626/11984_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: Use of antimicrobial agents is one of the
important strategies to prevent oral diseases. These agents
vary in their abilities to deliver preventive and therapeutic
benefits.
Objectives: This invitro study was conducted to assess
antimicrobial efficacy of different toothpastes against various
oral pathogens.
Materials and Methods: A total of nine toothpastes in three
groups were tested for their antimicrobial activity against
Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC
25923), Streptococcus mutans (ATCC 0266P) and Candida
albicans (Laboratory Strain) by modified agar well diffusion
method. Statistical Analysis was performed using Minitab
Software. A p-value of less than 0.05 was considered
significant.
Results: Triclosan-based dental formulation with combination
of fluoride (1000ppm) exhibited higher antimicrobial activity
against test organisms than the combination of lower fluorideconcentration or sodium monofluorophosphate. Among herbal
dentifrices, formulation containing Neem, Pudina, Long, Babool,
Turmeric and Vajradanti showed significant antimicrobial activity
against all the four tested microorganisms (p<0.05). However,
against Streptococcus mutans, all three herbal products showed
significant antimicrobial activity. Homeo products showed least
antimicrobial activity on the tested strains. Formulation with
kreosotum, Plantago major and calendula was significantly
effective only against Streptococcus mutans.
Conclusion: In the present study, antimicrobial activity of the
toothpaste containing both triclosan and fluoride (1000ppm)
as active ingredients showed a significant difference (p< 0.05)
against all four tested microflora compared to that of with
lower fluoride-concentration or sodium monofluorophosphate.
Of herbal groups, the only dentifrice containing several
phytochemicals was found to be significantly effective and
comparable to triclosan-fluoride (1000ppm) formulation. Thus,
this herbal toothpaste can be used as alternative to triclosanbased formulations. However, these results might not be
clinically useful unless tested invivo. |
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| ISSN: | 2249-782X 0973-709X |