Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum
Metronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of chitosan xanthan gum mixture. Hydrogel formation of this binary chitosan-xanthan gum combination was tested for its ability to control the release of metronidazole as a drug model. This prepara...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-05-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/8/5/1716/ |
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| author | Ala’a F. Eftaiha Nidal Qinna Iyad S. Rashid Mayyas M. Al Remawi Munther R. Al Shami Tawfiq A. Arafat Adnan A. Badwan |
| author_facet | Ala’a F. Eftaiha Nidal Qinna Iyad S. Rashid Mayyas M. Al Remawi Munther R. Al Shami Tawfiq A. Arafat Adnan A. Badwan |
| author_sort | Ala’a F. Eftaiha |
| collection | DOAJ |
| description | Metronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of chitosan xanthan gum mixture. Hydrogel formation of this binary chitosan-xanthan gum combination was tested for its ability to control the release of metronidazole as a drug model. This preparation (MZ-CR) was characterized by in vitro, ex vivo bioadhesion and in vivo bioavailability study. For comparison purposes a commercial extended release formulation of metronidazole (CMZ) was used as a reference. The in vitro drug-release profiles of metronidazole preparation and CMZ were similar in 0.1 M HCl and phosphate buffer pH 6.8. Moreover, metronidazole preparation and CMZ showed a similar detachment force to sheep stomach mucosa, while the bioadhesion of the metronidazole preparation was higher three times than CMZ to sheep duodenum. The results of in vivo study indicated that the absorption of metronidazole from the preparation was faster than that of CMZ. Also, MZ-CR leads to higher metronidazole Cmax and AUC relative to that of the CMZ. This increase in bioavailability might be explained by the bioadhesion of the preparation at the upper part of the small intestine that could result in an increase in the overall intestinal transit time. As a conclusion, formulating chitosan-xanthan gum mixture as a hydrophilic polymer matrix resulted in a superior pharmacokinetic parameters translated by better rate and extent of absorption of metronidazole. |
| first_indexed | 2024-04-11T22:36:59Z |
| format | Article |
| id | doaj.art-aad86249e95c4028ae22864b311a6d51 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T22:36:59Z |
| publishDate | 2010-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-aad86249e95c4028ae22864b311a6d512022-12-22T03:59:11ZengMDPI AGMarine Drugs1660-33972010-05-01851716173010.3390/md8051716Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan GumAla’a F. EftaihaNidal QinnaIyad S. RashidMayyas M. Al RemawiMunther R. Al ShamiTawfiq A. ArafatAdnan A. BadwanMetronidazole, a common antibacterial drug, was incorporated into a hydrophilic polymer matrix composed of chitosan xanthan gum mixture. Hydrogel formation of this binary chitosan-xanthan gum combination was tested for its ability to control the release of metronidazole as a drug model. This preparation (MZ-CR) was characterized by in vitro, ex vivo bioadhesion and in vivo bioavailability study. For comparison purposes a commercial extended release formulation of metronidazole (CMZ) was used as a reference. The in vitro drug-release profiles of metronidazole preparation and CMZ were similar in 0.1 M HCl and phosphate buffer pH 6.8. Moreover, metronidazole preparation and CMZ showed a similar detachment force to sheep stomach mucosa, while the bioadhesion of the metronidazole preparation was higher three times than CMZ to sheep duodenum. The results of in vivo study indicated that the absorption of metronidazole from the preparation was faster than that of CMZ. Also, MZ-CR leads to higher metronidazole Cmax and AUC relative to that of the CMZ. This increase in bioavailability might be explained by the bioadhesion of the preparation at the upper part of the small intestine that could result in an increase in the overall intestinal transit time. As a conclusion, formulating chitosan-xanthan gum mixture as a hydrophilic polymer matrix resulted in a superior pharmacokinetic parameters translated by better rate and extent of absorption of metronidazole.http://www.mdpi.com/1660-3397/8/5/1716/metronidazolechitosanxanthan gumbioadhesionbioavailability |
| spellingShingle | Ala’a F. Eftaiha Nidal Qinna Iyad S. Rashid Mayyas M. Al Remawi Munther R. Al Shami Tawfiq A. Arafat Adnan A. Badwan Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum Marine Drugs metronidazole chitosan xanthan gum bioadhesion bioavailability |
| title | Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum |
| title_full | Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum |
| title_fullStr | Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum |
| title_full_unstemmed | Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum |
| title_short | Bioadhesive Controlled Metronidazole Release Matrix Based on Chitosan and Xanthan Gum |
| title_sort | bioadhesive controlled metronidazole release matrix based on chitosan and xanthan gum |
| topic | metronidazole chitosan xanthan gum bioadhesion bioavailability |
| url | http://www.mdpi.com/1660-3397/8/5/1716/ |
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