The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial
<strong>Background:</strong> Despite primary vaccination, infants under six months run a risk of infection with pertussis. <strong>Objective:</strong> To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. <strong...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Shiraz University of Medical Sciences
2019-09-01
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| Series: | Iranian Journal of Immunology |
| Subjects: | |
| Online Access: | http://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdf |
| Summary: | <strong>Background:</strong> Despite primary vaccination, infants under six months run a risk of infection with pertussis. <strong>Objective:</strong> To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. <strong>Methods:</strong> All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. <strong>Results:</strong> The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. <strong>Conclusion:</strong> Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. |
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| ISSN: | 1735-1383 1735-367X |