The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial
<strong>Background:</strong> Despite primary vaccination, infants under six months run a risk of infection with pertussis. <strong>Objective:</strong> To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. <strong...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2019-09-01
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| Series: | Iranian Journal of Immunology |
| Subjects: | |
| Online Access: | http://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdf |
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| author | Ayse Kilic Gulcin Otar Yener Aylin Yetim Mustafa Ozcetin Gulbin Gokcay Asuman Coban Zeynep Ince Beril Yasa Lutfiye Oksuz Funda Gungor Ugurlucan Nezahat Gurler |
| author_facet | Ayse Kilic Gulcin Otar Yener Aylin Yetim Mustafa Ozcetin Gulbin Gokcay Asuman Coban Zeynep Ince Beril Yasa Lutfiye Oksuz Funda Gungor Ugurlucan Nezahat Gurler |
| author_sort | Ayse Kilic |
| collection | DOAJ |
| description | <strong>Background:</strong> Despite primary vaccination, infants under six months run a risk of infection with pertussis. <strong>Objective:</strong> To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. <strong>Methods:</strong> All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. <strong>Results:</strong> The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. <strong>Conclusion:</strong> Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months. |
| first_indexed | 2024-12-10T08:25:01Z |
| format | Article |
| id | doaj.art-aad88d1d72cd4c82af2559df6bb5041f |
| institution | Directory Open Access Journal |
| issn | 1735-1383 1735-367X |
| language | English |
| last_indexed | 2024-12-10T08:25:01Z |
| publishDate | 2019-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Immunology |
| spelling | doaj.art-aad88d1d72cd4c82af2559df6bb5041f2022-12-22T01:56:15ZengShiraz University of Medical SciencesIranian Journal of Immunology1735-13831735-367X2019-09-0116322523410.22034/iji.2019.8027345569The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical TrialAyse Kilic0Gulcin Otar Yener1Aylin Yetim2Mustafa Ozcetin3Gulbin Gokcay4Asuman Coban5Zeynep Ince6Beril Yasa7Lutfiye Oksuz8Funda Gungor Ugurlucan9Nezahat Gurler10Department of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Pediatrics, Istanbul Medical School, Istanbul University, Istanbul, TurkeyIstanbul University Institute of Child Health, Istanbul, TurkeyDepartment of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Neonatalogy, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Obstetrics and Gynecology, Istanbul Medical School, Istanbul University, Istanbul, TurkeyDepartment of Microbiology, Istanbul Medical School, Istanbul University, Istanbul, Turkey<strong>Background:</strong> Despite primary vaccination, infants under six months run a risk of infection with pertussis. <strong>Objective:</strong> To determine the impact of early postpartum maternal pertussis vaccination on protecting infants from the disease. <strong>Methods:</strong> All mothers (n=405) who gave birth to healthy term infants were educated on the cocoon strategy. The mothers who consented were immunized with the tetanus-diphtheria-acellular pertussis vaccine within the first three postpartum days. All infants received their pertussis vaccines according to the national schedule. The anti-pertussis IgG titers of infants of thirty vaccinated mothers were compared with those of thirty unvaccinated mothers. <strong>Results:</strong> The pertussis antibody levels in the infants of vaccinated mothers were significantly higher than those of unvaccinated mothers at the mean infant age of 5.6 ± 1.2 months. Only 6 infants of vaccinated mothers exhibited pertussis-like symptoms, none of whom had positive pertussis PCR. Seventeen infants of unvaccinated mothers had pertussis-like symptoms, and 4 tested positive for pertussis PCR. <strong>Conclusion:</strong> Our results showed that maternal pertussis vaccination, administered within the first three postpartum days, may protect infants against pertussis in their first ten months.http://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdfInfantMaternal ImmunizationPertussis Vaccine |
| spellingShingle | Ayse Kilic Gulcin Otar Yener Aylin Yetim Mustafa Ozcetin Gulbin Gokcay Asuman Coban Zeynep Ince Beril Yasa Lutfiye Oksuz Funda Gungor Ugurlucan Nezahat Gurler The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial Iranian Journal of Immunology Infant Maternal Immunization Pertussis Vaccine |
| title | The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial |
| title_full | The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial |
| title_fullStr | The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial |
| title_full_unstemmed | The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial |
| title_short | The Impact of Early Postpartum Maternal Pertussis Vaccination on the Protection of Infants: A Randomized Clinical Trial |
| title_sort | impact of early postpartum maternal pertussis vaccination on the protection of infants a randomized clinical trial |
| topic | Infant Maternal Immunization Pertussis Vaccine |
| url | http://iji.sums.ac.ir/article_45569_5420465994cf7a14b8da8e82e137fa40.pdf |
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