Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice

Niuhuang Qingxin Wan ameliorates depressive-like behaviors and improves hippocampal neurogenesis through modulating TrkB/ERK/CREB signaling pathway in chronic restraint stress or corticosterone challenge mice

Introduction: Chronic stress-associated hormonal imbalance impairs hippocampal neurogenesis, contributing to depressive and anxiety behaviors. Targeting neurogenesis is thus a promising antidepressant therapeutic strategy. Niuhuang Qingxin Wan (NHQXW) is an herbal formula for mental disorders in Tra...

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Bibliographic Details
Main Authors: Qiaohui Du, Chong Gao, Bun Tsoi, Meiling Wu, Jiangang Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
Niuhuang Qingxin Wan
depression
hippocampal neurogenesis
neural stem cells
BDNF/TrkB/ERK/CREB pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1274343/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1274343/full

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