Two-sample Mendelian randomization study for schizophrenia and breast cancer
Purpose The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer. Methods Bidirectional two-sample Mendelian randomization (TSMR) was performed using genome-wide association study summary data from a total of 311,266 individ...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sungkyunkwan University School of Medi
2020-03-01
|
| Series: | Precision and Future Medicine |
| Subjects: | |
| Online Access: | http://www.pfmjournal.org/upload/pdf/pfm-2019-00093.pdf |
| _version_ | 1818382947581952000 |
|---|---|
| author | Soyeon Kim Kiwon Kim Woojae Myung Hyewon Lee Ho Kim Doh Kwan Kim Hong-Hee Won |
| author_facet | Soyeon Kim Kiwon Kim Woojae Myung Hyewon Lee Ho Kim Doh Kwan Kim Hong-Hee Won |
| author_sort | Soyeon Kim |
| collection | DOAJ |
| description | Purpose The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer. Methods Bidirectional two-sample Mendelian randomization (TSMR) was performed using genome-wide association study summary data from a total of 311,266 individuals. The causal relationship was estimated using an inverse-variance weighted method (IVW). For sensitivity analysis, weighted median, Mendelian randomization (MR)-Egger regression, and Mendelian randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were used. Results The study showed evidence of a causal association between schizophrenia and the risk of breast cancer. In the IVW analysis, the odds ratio for breast cancer per log odds increase in schizophrenia risk was 1.069 with a 95% confidence interval of 1.028 to 1.112 (P< 0.001). This liability was consistently observed using multiple sensitivity analyses (P< 0.05). By contrast, the TSMR analysis of an inverted direction revealed no significant impact of breast cancer on the risk of schizophrenia. Conclusion Our results suggested that schizophrenia and breast cancer may have shared biological backgrounds. Genetic factors associated with schizophrenia might be causally associated with the risk of breast cancer. |
| first_indexed | 2024-12-14T02:58:34Z |
| format | Article |
| id | doaj.art-aad9944bebd4409fbf87044caf105716 |
| institution | Directory Open Access Journal |
| issn | 2508-7940 2508-7959 |
| language | English |
| last_indexed | 2024-12-14T02:58:34Z |
| publishDate | 2020-03-01 |
| publisher | Sungkyunkwan University School of Medi |
| record_format | Article |
| series | Precision and Future Medicine |
| spelling | doaj.art-aad9944bebd4409fbf87044caf1057162022-12-21T23:19:34ZengSungkyunkwan University School of MediPrecision and Future Medicine2508-79402508-79592020-03-0141213010.23838/pfm.2019.0009368Two-sample Mendelian randomization study for schizophrenia and breast cancerSoyeon Kim0Kiwon Kim1Woojae Myung2Hyewon Lee3Ho Kim4Doh Kwan Kim5Hong-Hee Won6 Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Korea Department of Psychiatry, Veterans Health Service Medical Center, Seoul, Korea Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea Institute of Health and Environment, Seoul National University, Seoul, Korea Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Samsung Advanced Institute for Health Sciences & Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, KoreaPurpose The purpose of this study was to investigate whether the risk of schizophrenia is causally associated with the risk of breast cancer. Methods Bidirectional two-sample Mendelian randomization (TSMR) was performed using genome-wide association study summary data from a total of 311,266 individuals. The causal relationship was estimated using an inverse-variance weighted method (IVW). For sensitivity analysis, weighted median, Mendelian randomization (MR)-Egger regression, and Mendelian randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) were used. Results The study showed evidence of a causal association between schizophrenia and the risk of breast cancer. In the IVW analysis, the odds ratio for breast cancer per log odds increase in schizophrenia risk was 1.069 with a 95% confidence interval of 1.028 to 1.112 (P< 0.001). This liability was consistently observed using multiple sensitivity analyses (P< 0.05). By contrast, the TSMR analysis of an inverted direction revealed no significant impact of breast cancer on the risk of schizophrenia. Conclusion Our results suggested that schizophrenia and breast cancer may have shared biological backgrounds. Genetic factors associated with schizophrenia might be causally associated with the risk of breast cancer.http://www.pfmjournal.org/upload/pdf/pfm-2019-00093.pdfbreast neoplasmscausalitygenetic backgroundgenome-wide association studyschizophrenia |
| spellingShingle | Soyeon Kim Kiwon Kim Woojae Myung Hyewon Lee Ho Kim Doh Kwan Kim Hong-Hee Won Two-sample Mendelian randomization study for schizophrenia and breast cancer Precision and Future Medicine breast neoplasms causality genetic background genome-wide association study schizophrenia |
| title | Two-sample Mendelian randomization study for schizophrenia and breast cancer |
| title_full | Two-sample Mendelian randomization study for schizophrenia and breast cancer |
| title_fullStr | Two-sample Mendelian randomization study for schizophrenia and breast cancer |
| title_full_unstemmed | Two-sample Mendelian randomization study for schizophrenia and breast cancer |
| title_short | Two-sample Mendelian randomization study for schizophrenia and breast cancer |
| title_sort | two sample mendelian randomization study for schizophrenia and breast cancer |
| topic | breast neoplasms causality genetic background genome-wide association study schizophrenia |
| url | http://www.pfmjournal.org/upload/pdf/pfm-2019-00093.pdf |
| work_keys_str_mv | AT soyeonkim twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT kiwonkim twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT woojaemyung twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT hyewonlee twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT hokim twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT dohkwankim twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer AT hongheewon twosamplemendelianrandomizationstudyforschizophreniaandbreastcancer |