Mitochondrial Iron Metabolism: The Crucial Actors in Diseases
Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Ir...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/1/29 |
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| author | Geyan Duan Jianjun Li Yehui Duan Changbing Zheng Qiuping Guo Fengna Li Jie Zheng Jiayi Yu Peiwen Zhang Mengliao Wan Cimin Long |
| author_facet | Geyan Duan Jianjun Li Yehui Duan Changbing Zheng Qiuping Guo Fengna Li Jie Zheng Jiayi Yu Peiwen Zhang Mengliao Wan Cimin Long |
| author_sort | Geyan Duan |
| collection | DOAJ |
| description | Iron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Iron deficiency impairs mitochondrial metabolism and respiratory activity, while mitochondrial iron overload promotes ROS production during mitochondrial electron transport, thus promoting potential disease development. This review provides an overview of iron homeostasis, mitochondrial iron metabolism, and how mitochondrial iron imbalances-induced mitochondrial dysfunction contribute to diseases. |
| first_indexed | 2024-03-09T03:30:45Z |
| format | Article |
| id | doaj.art-aadaa13669b24e599a61a27060f0d3e3 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T03:30:45Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-aadaa13669b24e599a61a27060f0d3e32023-12-03T14:56:12ZengMDPI AGMolecules1420-30492022-12-012812910.3390/molecules28010029Mitochondrial Iron Metabolism: The Crucial Actors in DiseasesGeyan Duan0Jianjun Li1Yehui Duan2Changbing Zheng3Qiuping Guo4Fengna Li5Jie Zheng6Jiayi Yu7Peiwen Zhang8Mengliao Wan9Cimin Long10CAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCollege of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, ChinaCAS Key Laboratory of Agro-Ecological Processes in Subtropical Region, Hunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic Process, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaIron is a trace element necessary for cell growth, development, and cellular homeostasis, but insufficient or excessive level of iron is toxic. Intracellularly, sufficient amounts of iron are required for mitochondria (the center of iron utilization) to maintain their normal physiologic function. Iron deficiency impairs mitochondrial metabolism and respiratory activity, while mitochondrial iron overload promotes ROS production during mitochondrial electron transport, thus promoting potential disease development. This review provides an overview of iron homeostasis, mitochondrial iron metabolism, and how mitochondrial iron imbalances-induced mitochondrial dysfunction contribute to diseases.https://www.mdpi.com/1420-3049/28/1/29iron homeostasismitochondrial dysfunctiondiseases |
| spellingShingle | Geyan Duan Jianjun Li Yehui Duan Changbing Zheng Qiuping Guo Fengna Li Jie Zheng Jiayi Yu Peiwen Zhang Mengliao Wan Cimin Long Mitochondrial Iron Metabolism: The Crucial Actors in Diseases Molecules iron homeostasis mitochondrial dysfunction diseases |
| title | Mitochondrial Iron Metabolism: The Crucial Actors in Diseases |
| title_full | Mitochondrial Iron Metabolism: The Crucial Actors in Diseases |
| title_fullStr | Mitochondrial Iron Metabolism: The Crucial Actors in Diseases |
| title_full_unstemmed | Mitochondrial Iron Metabolism: The Crucial Actors in Diseases |
| title_short | Mitochondrial Iron Metabolism: The Crucial Actors in Diseases |
| title_sort | mitochondrial iron metabolism the crucial actors in diseases |
| topic | iron homeostasis mitochondrial dysfunction diseases |
| url | https://www.mdpi.com/1420-3049/28/1/29 |
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