ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

ORFeome Phage Display Reveals a Major Immunogenic Epitope on the S2 Subdomain of SARS-CoV-2 Spike Protein

The development of antibody therapies against SARS-CoV-2 remains a challenging task during the ongoing COVID-19 pandemic. All approved therapeutic antibodies are directed against the receptor binding domain (RBD) of the spike, and therefore lose neutralization efficacy against emerging SARS-CoV-2 va...

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Bibliographic Details
Main Authors: Rico Ballmann, Sven-Kevin Hotop, Federico Bertoglio, Stephan Steinke, Philip Alexander Heine, M. Zeeshan Chaudhry, Dieter Jahn, Boas Pucker, Fausto Baldanti, Antonio Piralla, Maren Schubert, Luka Čičin-Šain, Mark Brönstrup, Michael Hust, Stefan Dübel
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
phage display
epitope mapping
COVID-19
genomic library
NGS
Online Access:https://www.mdpi.com/1999-4915/14/6/1326

Internet

https://www.mdpi.com/1999-4915/14/6/1326

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