Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases
Metabolomics is a branch of ‘omics’ sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/7/418 |
| _version_ | 1797528819621429248 |
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| author | Adewale Victor Aderemi Ademola Olabode Ayeleso Oluboade Oluokun Oyedapo Emmanuel Mukwevho |
| author_facet | Adewale Victor Aderemi Ademola Olabode Ayeleso Oluboade Oluokun Oyedapo Emmanuel Mukwevho |
| author_sort | Adewale Victor Aderemi |
| collection | DOAJ |
| description | Metabolomics is a branch of ‘omics’ sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-à-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer’s disease, dementia, Parkinson’s disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward. |
| first_indexed | 2024-03-10T10:04:51Z |
| format | Article |
| id | doaj.art-aadd69ca746745c583c9b9d12b9d3016 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T10:04:51Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-aadd69ca746745c583c9b9d12b9d30162023-11-22T01:39:59ZengMDPI AGMetabolites2218-19892021-06-0111741810.3390/metabo11070418Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable DiseasesAdewale Victor Aderemi0Ademola Olabode Ayeleso1Oluboade Oluokun Oyedapo2Emmanuel Mukwevho3Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UKDepartment of Biochemistry, Adeleke University, Ede PMB 250, NigeriaDepartment of Biochemistry, Obafemi Awolowo University, Ile-Ife 220282, NigeriaDepartment of Biochemistry, Mafikeng Campus, North-West University, Mmabatho 2735, South AfricaMetabolomics is a branch of ‘omics’ sciences that utilises a couple of analytical tools for the identification of small molecules (metabolites) in a given sample. The overarching goal of metabolomics is to assess these metabolites quantitatively and qualitatively for their diagnostic, therapeutic, and prognostic potentials. Its use in various aspects of life has been documented. We have also published, howbeit in animal models, a few papers where metabolomic approaches were used in the study of metabolic disorders, such as metabolic syndrome, diabetes, and obesity. As the goal of every research is to benefit humankind, the purpose of this review is to provide insights into the applicability of metabolomics in medicine vis-à-vis its role in biomarker discovery for disease diagnosis and management. Here, important biomarkers with proven diagnostic and therapeutic relevance in the management of disease conditions, such as Alzheimer’s disease, dementia, Parkinson’s disease, inborn errors of metabolism (IEM), diabetic retinopathy, and cardiovascular disease, are noted. The paper also discusses a few reasons why most metabolomics-based laboratory discoveries are not readily translated to the clinic and how these could be addressed going forward.https://www.mdpi.com/2218-1989/11/7/418metabolomicsmetabolitesbiomarkersanalytical toolsdiseasesdiabetes |
| spellingShingle | Adewale Victor Aderemi Ademola Olabode Ayeleso Oluboade Oluokun Oyedapo Emmanuel Mukwevho Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases Metabolites metabolomics metabolites biomarkers analytical tools diseases diabetes |
| title | Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases |
| title_full | Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases |
| title_fullStr | Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases |
| title_full_unstemmed | Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases |
| title_short | Metabolomics: A Scoping Review of Its Role as a Tool for Disease Biomarker Discovery in Selected Non-Communicable Diseases |
| title_sort | metabolomics a scoping review of its role as a tool for disease biomarker discovery in selected non communicable diseases |
| topic | metabolomics metabolites biomarkers analytical tools diseases diabetes |
| url | https://www.mdpi.com/2218-1989/11/7/418 |
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