Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES

Tumor-targeted dual-starvation therapy based on redox-responsive micelle nanosystem with co-loaded LND and BPTES

The starvation therapy mediated by the lonidamine (LND) was limited by the low drug delivery efficiency, off-target effect and compensative glutamine metabolism. Herein, a hyaluronic acid (HA)-modified reduction-responsive micellar nanosystem co-loaded with glycolysis and glutamine metabolism inhibi...

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Bibliographic Details
Main Authors: Zhenxiang Fu, Huiping Du, Siyu Meng, Mengjiao Yao, Pan Zhao, Xiang Li, Xinmin Zheng, Zhang Yuan, Hui Yang, Kaiyong Cai, Liangliang Dai
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Materials Today Bio
Subjects:
Redox-responsive
Degradable micelle
Drug delivery nanosystem
Dual-starvation therapy
Metabolism suppression
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006422002472

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