Effects of donor smoking history on early post-transplant lung function measured by oscillometry
IntroductionPrior studies assessing outcomes of lung transplants from cigarette-smoking donors found mixed results. Oscillometry, a non-invasive test of respiratory impedance, detects changes in lung function of smokers prior to diagnosis of COPD, and identifies spirometrically silent episodes of re...
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Frontiers Media S.A.
2024-04-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1328395/full |
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| author | Natalia Belousova Natalia Belousova Natalia Belousova Albert Cheng John Matelski Anastasiia Vasileva Joyce K. Y. Wu Rasheed Ghany Tereza Martinu Tereza Martinu Clodagh M. Ryan Clodagh M. Ryan Chung-Wai Chow Chung-Wai Chow |
| author_facet | Natalia Belousova Natalia Belousova Natalia Belousova Albert Cheng John Matelski Anastasiia Vasileva Joyce K. Y. Wu Rasheed Ghany Tereza Martinu Tereza Martinu Clodagh M. Ryan Clodagh M. Ryan Chung-Wai Chow Chung-Wai Chow |
| author_sort | Natalia Belousova |
| collection | DOAJ |
| description | IntroductionPrior studies assessing outcomes of lung transplants from cigarette-smoking donors found mixed results. Oscillometry, a non-invasive test of respiratory impedance, detects changes in lung function of smokers prior to diagnosis of COPD, and identifies spirometrically silent episodes of rejection post-transplant. We hypothesise that oscillometry could identify abnormalities in recipients of smoking donor lungs and discriminate from non-smoking donors.MethodsThis prospective single-center cohort study analysed 233 double-lung recipients. Oscillometry was performed alongside routine conventional pulmonary function tests (PFT) post-transplant. Multivariable regression models were constructed to compare oscillometry and conventional PFT parameters between recipients of lungs from smoking vs non-smoking donors.ResultsThe analysis included 109 patients who received lungs from non-smokers and 124 from smokers. Multivariable analysis identified significant differences between recipients of smoking and non-smoking lungs in the oscillometric measurements R5-19, X5, AX, R5z and X5z, but no differences in %predicted FEV1, FEV1/FVC, %predicted TLC or %predicted DLCO. An analysis of the smoking group also demonstrated associations between increasing smoke exposure, quantified in pack years, and all the oscillometry parameters, but not the conventional PFT parameters.ConclusionAn interaction was identified between donor-recipient sex match and the effect of smoking. The association between donor smoking and oscillometry outcomes was significant predominantly in the female donor/female recipient group. |
| first_indexed | 2024-04-24T11:44:02Z |
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| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-24T11:44:02Z |
| publishDate | 2024-04-01 |
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| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-aade92dba3d9403b90c8c93b88110b1c2024-04-09T14:23:17ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-04-011110.3389/fmed.2024.13283951328395Effects of donor smoking history on early post-transplant lung function measured by oscillometryNatalia Belousova0Natalia Belousova1Natalia Belousova2Albert Cheng3John Matelski4Anastasiia Vasileva5Joyce K. Y. Wu6Rasheed Ghany7Tereza Martinu8Tereza Martinu9Clodagh M. Ryan10Clodagh M. Ryan11Chung-Wai Chow12Chung-Wai Chow13Toronto Lung Transplant Program, Ajmera Multi-Organ Transplant Program and Division of Respirology, University Health Network, Tonronto, ON, CanadaDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaPneumology, Aduch Cystic Fibrosis and Lung Transplantation Department, Foch Hospital, Suresnes, FranceDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaPneumology, Aduch Cystic Fibrosis and Lung Transplantation Department, Foch Hospital, Suresnes, FranceDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaToronto General Pulmonary Function Laboratory, University Health Network, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Multi-Organ Transplant Program and Division of Respirology, University Health Network, Tonronto, ON, CanadaToronto Lung Transplant Program, Ajmera Multi-Organ Transplant Program and Division of Respirology, University Health Network, Tonronto, ON, CanadaDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaToronto General Pulmonary Function Laboratory, University Health Network, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Multi-Organ Transplant Program and Division of Respirology, University Health Network, Tonronto, ON, CanadaDepartment of Medicine, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, CanadaIntroductionPrior studies assessing outcomes of lung transplants from cigarette-smoking donors found mixed results. Oscillometry, a non-invasive test of respiratory impedance, detects changes in lung function of smokers prior to diagnosis of COPD, and identifies spirometrically silent episodes of rejection post-transplant. We hypothesise that oscillometry could identify abnormalities in recipients of smoking donor lungs and discriminate from non-smoking donors.MethodsThis prospective single-center cohort study analysed 233 double-lung recipients. Oscillometry was performed alongside routine conventional pulmonary function tests (PFT) post-transplant. Multivariable regression models were constructed to compare oscillometry and conventional PFT parameters between recipients of lungs from smoking vs non-smoking donors.ResultsThe analysis included 109 patients who received lungs from non-smokers and 124 from smokers. Multivariable analysis identified significant differences between recipients of smoking and non-smoking lungs in the oscillometric measurements R5-19, X5, AX, R5z and X5z, but no differences in %predicted FEV1, FEV1/FVC, %predicted TLC or %predicted DLCO. An analysis of the smoking group also demonstrated associations between increasing smoke exposure, quantified in pack years, and all the oscillometry parameters, but not the conventional PFT parameters.ConclusionAn interaction was identified between donor-recipient sex match and the effect of smoking. The association between donor smoking and oscillometry outcomes was significant predominantly in the female donor/female recipient group.https://www.frontiersin.org/articles/10.3389/fmed.2024.1328395/fulllung transplantoscillometrydonor smoking historydonor selectionlung function |
| spellingShingle | Natalia Belousova Natalia Belousova Natalia Belousova Albert Cheng John Matelski Anastasiia Vasileva Joyce K. Y. Wu Rasheed Ghany Tereza Martinu Tereza Martinu Clodagh M. Ryan Clodagh M. Ryan Chung-Wai Chow Chung-Wai Chow Effects of donor smoking history on early post-transplant lung function measured by oscillometry Frontiers in Medicine lung transplant oscillometry donor smoking history donor selection lung function |
| title | Effects of donor smoking history on early post-transplant lung function measured by oscillometry |
| title_full | Effects of donor smoking history on early post-transplant lung function measured by oscillometry |
| title_fullStr | Effects of donor smoking history on early post-transplant lung function measured by oscillometry |
| title_full_unstemmed | Effects of donor smoking history on early post-transplant lung function measured by oscillometry |
| title_short | Effects of donor smoking history on early post-transplant lung function measured by oscillometry |
| title_sort | effects of donor smoking history on early post transplant lung function measured by oscillometry |
| topic | lung transplant oscillometry donor smoking history donor selection lung function |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1328395/full |
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